Protein Information

Name SGT1
Synonyms ECD; GCR2; SGT 1; SGT1; Ecdysoneless homolog; GCR 2; HSGT 1; HSGT1…

Compound Information

Name abscisic acid
CAS

Reference List

PubMed Abstract RScore(About this table)
17991845 Johnston CA, Temple BR, Chen JG, Gao Y, Moriyama EN, Jones AM, Siderovski DP, Willard FS: Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid". Science. 2007 Nov 9;318(5852):914; author reply 914.

Liu et al. (Reports, 23 March 2007, p. 1712) reported that the Arabidopsis thaliana gene GCR2 encodes a seven-transmembrane, G protein-coupled receptor for abscisic acid.
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19513236 Chen JG: Heterotrimeric G-protein signaling in Arabidopsis: Puzzling G-protein-coupled receptor. Plant Signal Behav. 2008 Dec;3(12):1042-5.

In Arabidopsis thaliana, GCR2 has been proposed as a GPCR for the plant hormone abscisic acid.
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17894782 Gao Y, Zeng Q, Guo J, Cheng J, Ellis BE, Chen JG: Genetic characterization reveals no role for the reported ABA receptor, GCR2, in ABA control of seed germination and early seedling development in Arabidopsis. Plant J. 2007 Dec;52(6):1001-13. Epub 2007 Sep 25.

Abscisic acid (ABA) is perceived by several different types of receptors in plant cells.
At the cell surface, the ABA signal is proposed to be perceived by GCR2, which mediates ABA responses in seed germination, early seedling development and stomatal movement.
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18714360 Guo J, Zeng Q, Emami M, Ellis BE, Chen JG: The GCR2 gene family is not required for ABA control of seed germination and early seedling development in Arabidopsis. PLoS One. 2008 Aug 20;3(8):e2982.

BACKGROUND: The plant hormone abscisic acid (ABA) regulates diverse processes of plant growth and development.
However, the structural relationships and functionality of GCR2 have been challenged by several independent studies.
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18723578 Nakashima A, Chen L, Thao NP, Fujiwara M, Wong HL, Kuwano M, Umemura K, Shirasu K, Kawasaki T, Shimamoto K: RACK1 functions in rice innate immunity by interacting with the Rac1 immune complex. Plant Cell. 2008 Aug;20(8):2265-79. Epub 2008 Aug 22.

RACK1A was shown to interact with the N terminus of NADPH oxidase, RAR1, and SGT1, key regulators of plant disease resistance.
RACK1A transcription was also induced by a fungal elicitor and by abscisic acid, jasmonate, and auxin.
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19825556 Llorente F, Muskett P, Sanchez-Vallet A, Lopez G, Ramos B, Sanchez-Rodriguez C, Jorda L, Parker J, Molina A: Repression of the auxin response pathway increases Arabidopsis susceptibility to necrotrophic fungi. Mol Plant. 2008 May;1(3):496-509.

In plants, resistance to necrotrophic pathogens depends on the interplay between different hormone systems, such as those regulated by salicylic acid (SA), jasmonic acid (JA), ethylene, and abscisic acid.
SGT1b (one of two Arabidopsis SGT1 genes encoding HSP90/HSC70 co-chaperones) promotes the functions of SCF E3-ubiquitin ligase complexes in auxin and JA responses and resistance conditioned by certain Resistance (R) genes to biotrophic pathogens.
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19841654 Chen JG, Ellis BE: GCR2 is a new member of the eukaryotic lanthionine synthetase component C-like protein family. Plant Signal Behav. 2008 May;3(5):307-10.

GCR2 was recently proposed to represent a G-protein-coupled receptor (GPCR) for the plant hormone, abscisic acid (ABA).
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18086512 Illingworth CJ, Parkes KE, Snell CR, Mullineaux PM, Reynolds CA: Criteria for confirming sequence periodicity identified by Fourier transform analysis: application to GCR2, a candidate plant GPCR?. Biophys Chem. 2008 Mar;133(1-3):28-35. Epub 2007 Nov 22.

GCR2 has recently been proposed as the plant GPCR receptor for the hormone abscisic acid.
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