Protein Information

Name putative G protein coupled receptor
Synonyms GPCR; Putative G protein coupled receptor

Compound Information

Name abscisic acid
CAS

Reference List

PubMed Abstract RScore(About this table)
18086512 Illingworth CJ, Parkes KE, Snell CR, Mullineaux PM, Reynolds CA: Criteria for confirming sequence periodicity identified by Fourier transform analysis: application to GCR2, a candidate plant GPCR?. Biophys Chem. 2008 Mar;133(1-3):28-35. Epub 2007 Nov 22.

GCR2 has recently been proposed as the plant GPCR receptor for the hormone abscisic acid.
84(1,1,1,4) Details
15155892 Pandey S, Assmann SM: The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. Plant Cell. 2004 Jun;16(6):1616-32. Epub 2004 May 21.
81(1,1,1,1) Details
19135895 Pandey S, Nelson DC, Assmann SM: Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. Cell. 2009 Jan 9;136(1):136-48.
33(0,1,1,3) Details
19841654 Chen JG, Ellis BE: GCR2 is a new member of the eukaryotic lanthionine synthetase component C-like protein family. Plant Signal Behav. 2008 May;3(5):307-10.

GCR2 was recently proposed to represent a G-protein-coupled receptor (GPCR) for the plant hormone, abscisic acid (ABA).
31(0,1,1,1) Details
19513236 Chen JG: Heterotrimeric G-protein signaling in Arabidopsis: Puzzling G-protein-coupled receptor. Plant Signal Behav. 2008 Dec;3(12):1042-5.

In Arabidopsis thaliana, GCR2 has been proposed as a GPCR for the plant hormone abscisic acid.
6(0,0,1,1) Details
19826234 Tuteja N: Signaling through G protein coupled receptors. . Plant Signal Behav. 2009 Oct;4(10):942-7. Epub 2009 Oct 14.


Upon activation by a ligand, the GPCR undergoes a conformational change and then activate the G proteins by promoting the exchange of GDP/GTP associated with the Galpha subunit.
5(0,0,0,5) Details
16263907 Hsieh MH, Goodman HM: A novel gene family in Arabidopsis encoding putative heptahelical transmembrane proteins homologous to human adiponectin receptors and progestin receptors. J Exp Bot. 2005 Dec;56(422):3137-47. Epub 2005 Nov 1.

Although a fish mPR has been suggested to be a GPCR, human AdipoRs seem to be structurally and functionally distinct from all known GPCRs.
Steady-state levels of HHP1 mRNA are increased by treatments with abscisic acid and gibberellic acid, whereas levels of HHP2 mRNA are increased by abscisic acid and benzyladenine treatments.
1(0,0,0,1) Details
17894782 Gao Y, Zeng Q, Guo J, Cheng J, Ellis BE, Chen JG: Genetic characterization reveals no role for the reported ABA receptor, GCR2, in ABA control of seed germination and early seedling development in Arabidopsis. Plant J. 2007 Dec;52(6):1001-13. Epub 2007 Sep 25.

Abscisic acid (ABA) is perceived by several different types of receptors in plant cells.
GCR2 was also proposed to be a seven-transmembrane (7TM) G-protein-coupled receptor (GPCR).
1(0,0,0,1) Details