Protein Information

Name protein phosphatase 2C
Synonyms PDH; Pyruvate dehydrogenase phosphatase; PDP; PDP 1; PDP1; PDPC; PDPC 1; PDPC1…

Compound Information

Name abscisic acid
CAS

Reference List

PubMed Abstract RScore(About this table)
19266168 Komatsu K, Nishikawa Y, Ohtsuka T, Taji T, Quatrano RS, Tanaka S, Sakata Y: Functional analyses of the ABI1-related protein phosphatase type 2C reveal evolutionarily conserved regulation of abscisic acid signaling between Arabidopsis and the moss Physcomitrella patens. Plant Mol Biol. 2009 Jun;70(3):327-40. Epub 2009 Mar 6.

We employed a comparative genomic approach to understand protein phosphatase 2C (PP2C)-mediated abscisic acid (ABA) signaling in the moss Physcomitrella patens.
81(1,1,1,1) Details
19381642 Hu X, Zhang H, Li G, Yang Y, Zheng Z, Song F: Ectopic expression of a rice protein phosphatase 2C gene OsBIPP2C2 in tobacco improves disease resistance. Plant Cell Rep. 2009 Jun;28(6):985-95. Epub 2009 Apr 19.

Protein phosphatase 2Cs (PP2Cs) have been demonstrated to play critical roles in regulation of plant growth/development, abscisic acid signaling pathway and adaptation to environmental stresses.
9(0,0,1,4) Details
16339800 Yoshida T, Nishimura N, Kitahata N, Kuromori T, Ito T, Asami T, Shinozaki K, Hirayama T: ABA-hypersensitive germination3 encodes a protein phosphatase 2C (AtPP2CA) that strongly regulates abscisic acid signaling during germination among Arabidopsis protein phosphatase 2Cs. Plant Physiol. 2006 Jan;140(1):115-26. Epub 2005 Dec 9.
7(0,0,1,2) Details
16815952 Reyes D, Rodriguez D, Gonzalez-Garcia MP, Lorenzo O, Nicolas G, Garcia-Martinez JL, Nicolas C: Overexpression of a protein phosphatase 2C from beech seeds in Arabidopsis shows phenotypes related to abscisic acid responses and gibberellin biosynthesis. Plant Physiol. 2006 Aug;141(4):1414-24. Epub 2006 Jun 30.
6(0,0,1,1) Details
17461784 Nishimura N, Yoshida T, Kitahata N, Asami T, Shinozaki K, Hirayama T: ABA-Hypersensitive Germination1 encodes a protein phosphatase 2C, an essential component of abscisic acid signaling in Arabidopsis seed. Plant J. 2007 Jun;50(6):935-49. Epub 2007 Apr 25.
6(0,0,1,1) Details
19880399 Fujita Y, Nakashima K, Yoshida T, Katagiri T, Kidokoro S, Kanamori N, Umezawa T, Fujita M, Maruyama K, Ishiyama K, Kobayashi M, Nakasone S, Yamada K, Ito T, Shinozaki K, Yamaguchi-Shinozaki K: Three SnRK2 protein kinases are the main positive regulators of abscisic acid signaling in response to water stress in Arabidopsis. Plant Cell Physiol. 2009 Dec;50(12):2123-32. Epub .

Almost all dehydration-responsive LEA (late embryogenesis abundant) protein genes and group-A PP2C (protein phosphatase 2C) genes are strongly down-regulated in the srk2d/e/i triple mutants.
1(0,0,0,1) Details
16876791 Robert N, Merlot S, N'guyen V, Boisson-Dernier A, Schroeder JI: A hypermorphic mutation in the protein phosphatase 2C HAB1 strongly affects ABA signaling in Arabidopsis. FEBS Lett. 2006 Aug 21;580(19):4691-6. Epub 2006 Jul 24.

In Arabidopsis thaliana, the HAB1 PP2C is a negative regulator of the stress hormone abscisic acid (ABA) signaling.
1(0,0,0,1) Details
16614222 Mishra G, Zhang W, Deng F, Zhao J, Wang X: A bifurcating pathway directs abscisic acid effects on stomatal closure and opening in Arabidopsis. Science. 2006 Apr 14;312(5771):264-6.

Here, we show that phospholipase Dalpha1 (PLDalpha1) mediates the ABA effects on stomata through interaction with a protein phosphatase 2C (PP2C) and a heterotrimeric GTP-binding protein (G protein) in Arabidopsis.
1(0,0,0,1) Details
19705149 Ludwikow A, Kierzek D, Gallois P, Zeef L, Sadowski J: Gene expression profiling of ozone-treated Arabidopsis abi1td insertional mutant: protein phosphatase 2C ABI1 modulates biosynthesis ratio of ABA and ethylene. Planta. 2009 Oct;230(5):1003-17. Epub 2009 Aug 25.

We report on the characterization of the interaction between reactive oxygen species signalling and abscisic acid (ABA)-mediated gene network in ozone (O (3)) stress response.
1(0,0,0,1) Details
15197253 Zhang W, Qin C, Zhao J, Wang X: Phospholipase D alpha 1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and regulates abscisic acid signaling. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9508-13. Epub 2004 Jun 14.

Phospholipase D (PLD) and protein phosphatase 2C (PP2C) both play a role in mediating plant responses to abscisic acid (ABA).
1(0,0,0,1) Details
20097789 Tougane K, Komatsu K, Bhyan SB, Sakata Y, Ishizaki K, Yamato KT, Kohchi T, Takezawa D: Evolutionarily conserved regulatory mechanisms of abscisic acid signaling in land plants: characterization of ABSCISIC ACID INSENSITIVE1-like type 2C protein phosphatase in the liverwort Marchantia polymorpha. Plant Physiol. 2010 Mar;152(3):1529-43. Epub 2010 Jan 22.

The MpABI1 cDNA encoded a 568-amino acid protein consisting of the carboxy-terminal protein phosphatase 2C (PP2C) domain and a novel amino-terminal regulatory domain.
1(0,0,0,1) Details
18930563 Liu L, Hu X, Song J, Zong X, Li D, Li D: Over-expression of a Zea mays L. protein phosphatase 2C gene (ZmPP2C) in Arabidopsis thaliana decreases tolerance to salt and drought. J Plant Physiol. 2009 Mar 15;166(5):531-42. Epub 2008 Oct 18.

1(0,0,0,1) Details
18298671 Moes D, Himmelbach A, Korte A, Haberer G, Grill E: Nuclear localization of the mutant protein phosphatase abi1 is required for insensitivity towards ABA responses in Arabidopsis. Plant J. 2008 Jun;54(5):806-19. Epub 2008 Feb 22.


ABI1, a protein phosphatase 2C, is a key component of ABA signal transduction in Arabidopsis that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth.
1(0,0,0,1) Details
19874541 Nishimura N, Sarkeshik A, Nito K, Park SY, Wang A, Carvalho PC, Lee S, Caddell DF, Cutler SR, Chory J, Yates JR, Schroeder JI: PYR/PYL/RCAR family members are major in-vivo ABI1 protein phosphatase 2C-interacting proteins in Arabidopsis. Plant J. 2010 Jan;61(2):290-9. Epub 2009 Oct 26.

Abscisic acid (ABA) mediates resistance to abiotic stress and controls developmental processes in plants.
1(0,0,0,1) Details
19805022 Umezawa T, Sugiyama N, Mizoguchi M, Hayashi S, Myouga F, Yamaguchi-Shinozaki K, Ishihama Y, Hirayama T, Shinozaki K: Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17588-93. Epub 2009 Sep 29.

0(0,0,0,0) Details
19690149 Zhang Y, Zhu H, Zhang Q, Li M, Yan M, Wang R, Wang L, Welti R, Zhang W, Wang X: Phospholipase dalpha1 and phosphatidic acid regulate NADPH oxidase activity and production of reactive oxygen species in ABA-mediated stomatal closure in Arabidopsis. Plant Cell. 2009 Aug;21(8):2357-77. Epub 2009 Aug 18.


We determined the role of Phospholipase Dalpha1 (PLDalpha1) and its lipid product phosphatidic acid (PA) in abscisic acid (ABA)-induced production of reactive oxygen species (ROS) in Arabidopsis thaliana guard cells.
0(0,0,0,0) Details