Protein Information

Name P5CS
Synonyms ALDH18A1; Aldehyde dehydrogenase 18 family member A1; Delta 1 pyrroline 5 carboxylate synthetase; GSAS; Glutamate gamma semialdehyde synthetase; P5CS; PYCS; Pyrroline 5 carboxylate synthetase…

Compound Information

Name abscisic acid
CAS

Reference List

PubMed Abstract RScore(About this table)
17971042 Szekely G, Abraham E, Cseplo A, Rigo G, Zsigmond L, Csiszar J, Ayaydin F, Strizhov N, Jasik J, Schmelzer E, Koncz C, Szabados L: Duplicated P5CS genes of Arabidopsis play distinct roles in stress regulation and developmental control of proline biosynthesis. Plant J. 2008 Jan;53(1):11-28. Epub 2007 Oct 27.

Transcription of the P5CS genes is differentially regulated by drought, salinity and abscisic acid, suggesting that these genes play specific roles in the control of proline biosynthesis.
10(0,0,1,5) Details
18054243 Silva-Ortega CO, Ochoa-Alfaro AE, Reyes-Aguero JA, Aguado-Santacruz GA, Jimenez-Bremont JF: Salt stress increases the expression of p5cs gene and induces proline accumulation in cactus pear. Plant Physiol Biochem. 2008 Jan;46(1):82-92. Epub 2007 Oct 12.


In the present study, we measured the Pro content, the activity and the expression level of delta 1-pyrroline-5-carboxylate synthetase (P5CS: gamma-glutamyl kinase, EC 2.7.2.11 and glutamate-5-semialdehyde dehydrogenase, EC 1.2.1.41), a key regulatory enzyme involved in the biosynthesis of Pro, in cactus pear (Opuntia streptacantha) subjected to 6, 9 and 11 days of salt stress.
3(0,0,0,3) Details
15247402 Taji T, Seki M, Satou M, Sakurai T, Kobayashi M, Ishiyama K, Narusaka Y, Narusaka M, Zhu JK, Shinozaki K: Comparative genomics in salt tolerance between Arabidopsis and aRabidopsis-related halophyte salt cress using Arabidopsis microarray. Plant Physiol. 2004 Jul;135(3):1697-709. Epub 2004 Jul 9.


Notably a large number of known abiotic- and biotic-stress inducible genes, including Fe-SOD, P5CS, PDF1.2, AtNCED, P-protein, beta-glucosidase, and SOS1, were expressed in salt cress at high levels even in the absence of stress.
1(0,0,0,1) Details
19192390 Xue X, Liu A, Hua X: Proline accumulation and transcriptional regulation of proline biosynthesis and degradation in Brassica napus. BMB Rep. 2009 Jan 31;42(1):28-34.


To understand the molecular mechanism underlying proline accumulation in Brassica napus, cDNAs encoding Delta (1)-pyrroline-5-carboxylate synthetase (BnP5CS), ornithine delta-aminotransferase (BnOAT) and proline dehydrogenase (BnPDH) were isolated and characterized.
1(0,0,0,1) Details
18713445 Liao Y, Zhang JS, Chen SY, Zhang WK: Role of soybean GmbZIP132 under abscisic acid and salt stresses. J Integr Plant Biol. 2008 Feb;50(2):221-30.

The expression of some abiotic stress-related genes, such as rd29B, DREB2A, and P5CS, were upregulated in the transgenic plants.
1(0,0,0,1) Details
15809861 Miller G, Stein H, Honig A, Kapulnik Y, Zilberstein A: Responsive modes of Medicago sativa proline dehydrogenase genes during salt stress and recovery dictate free proline accumulation. Planta. 2005 Sep;222(1):70-9. Epub 2005 Apr 5.


Estimation of transcript levels during salt stress and recovery revealed that proline accumulation during stress was linearly correlated with a strong decline in MsPDH transcript levels, while Delta (1) -pyrroline-5-carboxylate synthetase (MsP5CS) and MsP5CDH steady-state transcript levels remained essentially unchanged.
1(0,0,0,1) Details
15998313 Chen Z, Hong X, Zhang H, Wang Y, Li X, Zhu JK, Gong Z: Disruption of the cellulose synthase gene, AtCesA8/IRX1, enhances drought and osmotic stress tolerance in Arabidopsis. Plant J. 2005 Jul;43(2):273-83.

The mutants were more tolerant to drought stress as well as to NaCl, mannitol and other osmotic stresses. lew2 mutant plants accumulated more abscisic acid (ABA), proline and soluble sugars than the wild type.
The expression of a stress-inducible marker gene RD29A, a proline synthesis-related gene P5CS (pyrroline-5-carboxylate synthase) and an ABA synthesis-related gene SDR1 (alcohol dehydrogenase/reductase) was higher in lew2 than in the wild type.
1(0,0,0,1) Details