Protein Information

Name G protein alpha (protein family or complex)
Synonyms G protein alpha; Guanine nucleotide binding protein alpha

Compound Information

Name abscisic acid
CAS

Reference List

PubMed Abstract RScore(About this table)
17999646 Ding L, Pandey S, Assmann SM: Arabidopsis extra-large G proteins (XLGs) regulate root morphogenesis. Plant J. 2008 Jan;53(2):248-63. Epub 2007 Nov 12.


Besides the sole prototypical G protein alpha subunit gene, GPA1, the Arabidopsis thaliana genome has three extra-large GTP-binding protein (XLG)-encoding genes: XLG1 (At2g23460), XLG2 (At4g34390) and XLG3 (At1g31930).
1(0,0,0,1) Details
15665242 Coursol S, Le Stunff H, Lynch DV, Gilroy S, Assmann SM, Spiegel S: Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture. Plant Physiol. 2005 Feb;137(2):724-37. Epub 2005 Jan 21.

Recently, we have shown that the enzyme responsible for S1P production, sphingosine kinase (SphK), is stimulated by the phytohormone abscisic acid in guard cells of Arabidopsis (Arabidopsis thaliana) and that S1P is effective in regulating guard cell turgor.
Importantly, we found that phytosphingosine-1-phosphate, similar to S1P, regulates stomatal apertures and that its action is impaired in guard cells of Arabidopsis plants harboring T-DNA null mutations in the sole prototypical G-protein alpha-subunit gene, GPA1.
1(0,0,0,1) Details
17894782 Gao Y, Zeng Q, Guo J, Cheng J, Ellis BE, Chen JG: Genetic characterization reveals no role for the reported ABA receptor, GCR2, in ABA control of seed germination and early seedling development in Arabidopsis. Plant J. 2007 Dec;52(6):1001-13. Epub 2007 Sep 25.

On the other hand, the loss-of-function alleles of the sole Arabidopsis heterotrimeric G protein alpha subunit, GPA1, were hypersensitive to ABA in the ABA-inhibition of seed germination and early seedling development, disfavoring a genetic coupling of GCR2 by GPA1.
Abscisic acid (ABA) is perceived by several different types of receptors in plant cells.
1(0,0,0,1) Details
19135895 Pandey S, Nelson DC, Assmann SM: Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis. Cell. 2009 Jan 9;136(1):136-48.

We identify and characterize two novel Arabidopsis proteins that show homology to an orphan vertebrate GPCR (GPR89) and interact with the sole Arabidopsis G protein alpha subunit, GPA1, but also have intrinsic GTP-binding and GTPase activity.
1(0,0,0,1) Details
20166762 Zhao Z, Stanley BA, Zhang W, Assmann SM: ABA-Regulated G Protein Signaling in Arabidopsis Guard Cells: A Proteomic Perspective. J Proteome Res. 2010 Mar 10.


In the model plant Arabidopsis thaliana, the sole canonical G protein alpha subunit, GPA1, has been implicated in multiple signaling events, including guard cell movement regulated by the plant stress hormone abscisic acid (ABA).
1(0,0,0,1) Details
19513236 Chen JG: Heterotrimeric G-protein signaling in Arabidopsis: Puzzling G-protein-coupled receptor. Plant Signal Behav. 2008 Dec;3(12):1042-5.

In Arabidopsis thaliana, GCR2 has been proposed as a GPCR for the plant hormone abscisic acid.
On the other hand, biochemical analysis demonstrates that the sole Arabidopsis heterotrimeric G-protein alpha subunit, GPA1, is in the activated state (GTP-bound) by default, suggesting that the heterotrimeric G-proteins may act without any GPCRs.
1(0,0,0,1) Details
17347412 Liu X, Yue Y, Li B, Nie Y, Li W, Wu WH, Ma L: A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid. Science. 2007 Mar 23;315(5819):1712-6. Epub 2007 Mar 8.

Here, we report that a G protein-coupled receptor genetically and physically interacts with the G protein alpha subunit GPA1 to mediate all known ABA responses in Arabidopsis.
1(0,0,0,1) Details
15155892 Pandey S, Assmann SM: The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. Plant Cell. 2004 Jun;16(6):1616-32. Epub 2004 May 21.
31(0,1,1,1) Details
20238175 Gao Y, Li T, Liu Y, Ren C, Zhao Y, Wang M: Isolation and characterization of gene encoding G protein alpha subunit protein responsive to plant hormones and abiotic stresses in Brassica napus. Mol Biol Rep. 2010 Mar 18.

The expression of BnGA1 was significantly induced by the high concentrations of abscisic acid (ABA) and brassinosteroid (BR).
2(0,0,0,2) Details