Protein Information

Name lactate dehydrogenase (protein family or complex)
Synonyms LDH; lactate dehydrogenase; lactate dehydrogenases

Compound Information

Name permethrin
CAS (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
10576906 Singh A, Srivastava VK: Toxic effect of synthetic pyrethroid permethrin on the enzyme system of the freshwater fish Channa striatus. Chemosphere. 1999 Nov;39(11):1951-6.

Treatment with 40% and 80% of the LC50 (24h) of the pyrethroid permethrin after 24h exposure causes significant reduction in the activity of lactate dehydrogenase and cytochrome oxidase and enhanced the succinate dehydrogenase activity in the tissues of the freshwater fish Channa striatus.
81(1,1,1,1) Details
15036745 Olgun S, Gogal RM Jr, Adeshina F, Choudhury H, Misra HP: Pesticide mixtures potentiate the toxicity in murine thymocytes. Toxicology. 2004 Mar 15;196(3):181-95.

C57BL/6 mouse thymocytes were exposed to lindane, malathion, and permethrin, either separately or in mixtures of two pesticides, in vitro.
These pesticide exposures caused both apoptotic and necrotic cell death in thymocytes as evaluated by flow cytometric analysis in combination with 7-aminoactinomycin-D (7-AAD), Annexin-V/propidium iodide (PI) staining assays and lactate dehydrogenase release assays.
1(0,0,0,1) Details
8258384 Kodavanti PR, Mundy WR, Tilson HA, Harry GJ: Effects of selected neuroactive chemicals on calcium transporting systems in rat cerebellum and on survival of cerebellar granule cells. Fundam Appl Toxicol. 1993 Oct;21(3):308-16.

Cytotoxicity (lactate dehydrogenase leakage) was assessed in primary cultures of cerebellar granule cells from 6- to 8-day-old Long-Evans rats.
However, chlorpromazine (CPZ), aluminum (Al), permethrin (PER), and deltamethrin (DEL) inhibited Ca2+ sequestration by mitochondria and microsomes.
1(0,0,0,1) Details