| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | permethrin |
|---|---|
| CAS | (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18260698 | Boone MD: Examining the single and interactive effects of three insecticides on amphibian metamorphosis. Environ Toxicol Chem. 2008 Jul;27(7):1561-8. I exposed tadpoles to single or multiple insecticides at approximately half the reported median lethal concentrations using insecticides that were either acetylcholinesterase inhibitors (carbaryl or malathion) or a sodium-channel disruptor (permethrin). |
31(0,1,1,1) | Details |
| 1459649 | Yasmeen N, Nayeemunnisa: Insecticide induced disruptions in functioning of developing brain of Rana cyanophlictis. Indian J Exp Biol. 1992 Aug;30(8):701-4. Remarkable inhibition of enzymes acetylcholinesterase and choline acetylase and significant accumulation of neurotransmitter were observed in permethrin treated animals. |
31(0,1,1,1) | Details |
| 14713564 | Abdel-Rahman A, Dechkovskaia AM, Goldstein LB, Bullman SH, Khan W, El-Masry EM, Abou-Donia MB: Neurological deficits induced by malathion, DEET, and permethrin, alone or in combination in adult rats. J Toxicol Environ Health A. 2004 Feb 27;67(4):331-56. Treatment with DEET or permethrin alone, malathion and permethrin, or DEET and permethrin produced significant increases in cortical acetylcholinesterase (AChE) activity. |
12(0,0,2,2) | Details |
| 12270692 | Abdel-Rahman A, Shetty AK, Abou-Donia MB: Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, dentate gyrus, thalamus, and hypothalamus in a rat model of Gulf-War syndrome. Neurobiol Dis. 2002 Aug;10(3):306-26. We investigated the effects of a combined exposure to restraint stress and low doses of chemicals pyridostigmine bromide (PB), N, N-diethyl-m-toluamide (DEET), and permethrin in adult male rats, a model of Gulf-War syndrome. All animals were evaluated for: (i) the disruption of the blood-brain barrier (BBB) using intravenous horseradish peroxidase (HRP) injections and endothelial barrier antigen (EBA) immunostaining; (ii) neuronal cell death using H&E; staining, silver staining, and glial fibrillary acidic protein (GFAP) immunostaining; and (iii) acetylcholinesterase (AChE) activity and m2-muscarinic acetylcholine receptors (m2-AChR). |
2(0,0,0,2) | Details |
| 11695191 | Clark JM, Lee SH, Kim HJ, Yoon KS, Zhang A: DNA-based genotyping techniques for the detection of point mutations associated with insecticide resistance in Colorado potato beetle Leptinotarsa decemlineata. Pest Manag Sci. 2001 Oct;57(10):968-74. Three DNA-based genotyping techniques, bi-directional PCR amplification of specific allele (bi-PASA), single-stranded conformational polymorphism (SSCP) and minisequencing, have been developed and compared for the detection of the S291G (insensitive acetylcholinesterase) and L1014F (insensitive sodium channel) mutations associated with azinphos-methyl and permethrin resistance, respectively, in the Colorado potato beetle (Leptinotarsa decemlineata). |
6(0,0,1,1) | Details |
| 15470232 | Lein PJ, Fryer AD: Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicol Sci. 2005 Jan;83(1):166-76. Epub 2004 Oct 6. Treatments that did not decrease M2 receptor function (parathion at 0.1 mg/kg, sc, or the non-OP insecticide permethrin at 150 mg/kg, sc) also did not cause airway hyperreactivity. |
3(0,0,0,3) | Details |
| 11841371 | Downs AM, Stafford KA, Hunt LP, Ravenscroft JC, Coles GC: Widespread insecticide resistance in head lice to the over-the-counter pediculocides in England, and the emergence of carbaryl resistance. Br J Dermatol. 2002 Jan;146(1):88-93. OBJECTIVES: To establish the extent of insecticide resistance in head lice and acetylcholinesterase activity in the presence of carbaryl in head lice. METHODS: Head lice were collected from school children in four centres across England (Exmouth, Loughborough, Leeds and South Shields), and tested in their response to the insecticides permethrin, phenothrin, malathion and carbaryl. |
3(0,0,0,3) | Details |
| 17568372 | Pethuan S, Jirakanjanakit N, Saengtharatip S, Chareonviriyaphap T, Kaewpa D, Rongnoparut P: Biochemical studies of insecticide resistance in Aedes (Stegomyia) aegypti and Aedes (Stegomyia) albopictus (Diptera: Culicidae) in Thailand. Trop Biomed. 2007 Jun;24(1):7-15. Biochemical analysis was performed on field caught Aedes (Stegomyia) aegypti and Aedes (Stegomyia) albopictus (Diptera: Culicidae) mosquitoes to determine activities of enzymes including mixed function oxidases (MFO), nonspecific esterases (alpha- and beta-), glutathione-S-transferases (GST), and insensitive acetylcholinesterase (AChE). The susceptibility to pyrethroids (deltamethrin, permethrin), organophosphate (fenitrothion) and (propoxur) insecticides were revealed in these samples. |
2(0,0,0,2) | Details |
| 11129708 | Karunaratne SH, Hemingway J: Insecticide resistance spectra and resistance mechanisms in populations of Japanese encephalitis vector mosquitoes, Culex tritaeniorhynchus and Cx. gelidus, in Sri Lanka. Med Vet Entomol. 2000 Dec;14(4):430-6. Using wild-caught adult mosquitoes from light traps, log dosage-probit mortality curves for insecticide bioassays were obtained for three insecticides: malathion (organophosphate), propoxur and permethrin (pyrethroid). Propoxur inhibition of acetylcholinesterase (AChE) activity (the target site of organophosphates and carbamates) indicated that in 1998, frequencies of insensitive AChE-based resistance were 9% in Cx. gelidus and 2-23% in Cx. tritaeniorhynchus, whereas in 1984 this resistance mechanism was detected only in 2% of the latter species from Anaradhapura. |
2(0,0,0,2) | Details |
| 14675905 | Abdel-Rahman A, Abou-Donia S, El-Masry E, Shetty A, Abou-Donia M: Stress and combined exposure to low doses of pyridostigmine bromide, DEET, and permethrin produce neurochemical and neuropathological alterations in cerebral cortex, hippocampus, and cerebellum. J Toxicol Environ Health A. 2004 Jan 23;67(2):163-92. Animals exposed to both stress and chemical exhibited decreased brain acetylcholinesterase (AChE) activity in the midbrain, brainstem, and cerebellum and decreased m2 muscarinic receptor ligand binding in the midbrain and cerebellum. |
1(0,0,0,1) | Details |
| 18755020 | Perera MD, Hemingway J, Karunaratne SP: Multiple insecticide resistance mechanisms involving metabolic changes and insensitive target sites selected in anopheline vectors of malaria in Sri Lanka. Malar J. 2008 Aug 28;7:168. METHODS: Adult females were exposed to the WHO discriminating dosages of DDT, malathion, fenitrothion, propoxur, lambda-cyhalothrin, cyfluthrin, cypermethrin, deltamethrin, permethrin and etofenprox. The presence of metabolic resistance by esterase, glutathione S-transferase (GST) and monooxygenase-based mechanisms, and the sensitivity of the acetylcholinesterase target site were assessed using synergists, and biochemical, and metabolic techniques. |
2(0,0,0,2) | Details |
| 8481527 | Rodriguez M, Ortiz E, Bisset JA, Hemingway J, Saledo E: Changes in malathion and pyrethroid resistance after cypermethrin selection of Culex quinquefasciatus field populations of Cuba. Med Vet Entomol. 1993 Apr;7(2):117-21. Use of the organophosphorus insecticide malathion for mosquito control in Cuba, for 7 years up to 1986, selected elevated non-specific esterase and altered acetylcholinesterase (AChE) resistance mechanisms in Culex quinquefasciatus. |
2(0,0,0,2) | Details |
| 15476966 | Foil LD, Coleman P, Eisler M, Fragoso-Sanchez H, Garcia-Vazquez Z, Guerrero FD, Jonsson NN, Langstaff IG, Li AY, Machila N, Miller RJ, Morton J, Pruett JH, Torr S: Factors that influence the prevalence of acaricide resistance and tick-borne diseases. Vet Parasitol. 2004 Oct 28;125(1-2):163-81. Acetylcholine esterase affinity for OPs is changed in resistant tick populations. A PCR-based assay to detect a specific sodium channel gene mutation that is associated with resistance to permethrin has been developed. |
2(0,0,0,2) | Details |
| 19038063 | Munhenga G, Masendu HT, Brooke BD, Hunt RH, Koekemoer LK: Pyrethroid resistance in the major malaria vector Anopheles arabiensis from Gwave, a malaria-endemic area in Zimbabwe. Malar J. 2008 Nov 28;7:247. METHODS: Standard WHO bioassays, using 0.75% permethrin, 4% DDT, 5% malathion, 0.1% bendiocarb and 4% dieldrin were performed on wild-collected adult anopheline mosquitoes and F1 progeny of An. arabiensis reared from wild-caught females. Biochemical assays were used to determine the relative levels of detoxifying enzyme systems including non-specific esterases, monooxygenases and glutathione-S-transferases as well as to detect the presence of an altered acetylcholine esterase (AChE). |
1(0,0,0,1) | Details |
| 9615543 | Ben Cheikh H, Ben Ali-Haouas Z, Marquine M, Pasteur N: Resistance to organophosphorus and pyrethroid insecticides in Culex pipiens (Diptera: Culicidae) from Tunisia. J Med Entomol. 1998 May;35(3):251-60. Resistance to the organophosphates temephos and chlorpyrifos, the propoxur, the pyrethroid permethrin, and the organochloride DDT was investigated in Tunisian populations of Culex pipiens pipiens (L.) collected between 1990 and 1996. To better understand the factors influencing the distribution of resistance in Tunisia, the polymorphism of genes involved in organophosphate resistance (i.e., over-produced esterases and insensitive acetylcholinesterase) was investigated in relation to the genetic structure of populations studied by analyzing the electrophoretic polymorphism of "neutral" genes. |
1(0,0,0,1) | Details |
| 17466253 | N'Guessan R, Boko P, Odjo A, Akogbeto M, Yates A, Rowland M: Chlorfenapyr: a pyrrole insecticide for the control of pyrethroid or DDT resistant Anopheles gambiae (Diptera: Culicidae) mosquitoes. Acta Trop. 2007 Apr;102(1):69-78. Epub 2007 Mar 12. Mortality rates in the kdr strain exposed to chlorfenapyr treated netting in tunnel tests were much higher than with permethrin treated netting over the same 100-500 mg/ dosage range. Performance against An. gambiae bearing kdr (pyrethroid and DDT resistance) or Ace-1 (R) insensitive acetylcholinesterase (organophosphate and resistance) mechanisms was studied using a variety of adult bioassay tests including a simulated-experimental hut system (tunnel tests) that allows uninhibited mosquito behaviour/insecticide interactions. |
1(0,0,0,1) | Details |
| 7572467 | Mourya DT, Hemingway J, Leake CJ: Post-inoculation changes in enzyme activity of Aedes aegypti infected with Chikungunya virus. Acta Virol. 1995 Feb;39(1):31-5. Levels of acetylcholinesterase, non-specific esterases, glutathione-S-transferase and glucose-6-phosphate dehydrogenase in Aedes aegypti (L.) mosquitoes inoculated intrathoracally with Chikungunya virus were elevated, as compared to uninoculated control insects. |
1(0,0,0,1) | Details |
| 18405930 | Okoye PN, Brooke BD, Koekemoer LL, Hunt RH, Coetzee M: Characterisation of DDT, pyrethroid and resistance in Anopheles funestus from Obuasi, Ghana. Trans R Soc Trop Med Hyg. 2008 Jun;102(6):591-8. Epub 2008 Apr 10. Samples of F1 progeny from each family were divided into cohorts and were either exposed to DDT and permethrin or were stored for biochemical analysis. Furthermore, an altered acetylcholinesterase conferring resistance was evident. |
1(0,0,0,1) | Details |
| 19274371 | Fonseca-Gonzalez I, Quinones ML, McAllister J, Brogdon WG: Mixed-function oxidases and esterases associated with cross-resistance between DDT and lambda-cyhalothrin in Anopheles darlingi Root 1926 populations from Colombia. Mem Inst Oswaldo Cruz. 2009 Feb;104(1):18-26. All field populations were susceptible to deltamethrin, permethrin, malathion and fenitrothion. Enzyme levels related to insecticide resistance, including mixed function oxidases (MFO), non-specific esterases (NSE), glutathione S-transferases and modified acetylcholinesterase were evaluated in all populations and compared with a susceptible natural strain. |
1(0,0,0,1) | Details |
| 15119600 | Corbel V, Raymond M, Chandre F, Darriet F, Hougard JM: Efficacy of insecticide mixtures against larvae of Culex quinquefasciatus (Say) (Diptera: Culicidae) resistant to pyrethroids and carbamates. Pest Manag Sci. 2004 Apr;60(4):375-80. The efficacy of insecticide mixtures of permethrin (pyrethroid) and propoxur was tested by larval bioassays on two strains of Culex quinquefasciatus (Say), one resistant to pyrethroids and the other resistant to carbamates. Nevertheless, antagonism in the R-LAB strain is probably due to a physiological perturbation implying different target sites for pyrethroid (ie sodium channel) and insecticides [ie acetylcholinesterase (EC 3.3.3.7) and choline acetyltransferase (EC 2.3.1.6)]. |
1(0,0,0,1) | Details |
| 10414780 | Butte W, Kemper K: A spectrophotometric assay for pyrethroid-cleaving enzymes in human serum. Toxicol Lett. 1999 Jun 30;107(1-3):49-53. These substrates show a structure very similar to the pyrethroids most often used (e.g. permethrin, cyfluthrin). |
0(0,0,0,0) | Details |
| 19303125 | Ramphul U, Boase T, Bass C, Okedi LM, Donnelly MJ, Muller P: Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda. Trans R Soc Trop Med Hyg. 2009 Nov;103(11):1121-6. Epub 2009 Mar 19. Anopheles gambiae s.l. adults were raised from wild-caught larvae sampled from two ecologically distinct breeding sites and exposed to WHO discriminating concentrations of DDT, permethrin, deltamethrin, bendiocarb and malathion. Using molecular diagnostics, susceptible and resistant specimens were further tested for the presence of knockdown resistance (kdr) and acetylcholinesterase 1 resistance (ace-1 (R)) alleles. |
1(0,0,0,1) | Details |
| 8723267 | Wirth MC, Georghiou GP: Organophosphate resistance in Culex pipiens from Cyprus. J Am Mosq Control Assoc. 1996 Mar;12(1):112-8. Of the 6 populations tested with permethrin, 2 were resistant to permethrin. Resistance was associated with the presence of 5 different overproduced esterases (esterases A1, A2, A5, B2, and B5) as well as an insensitive form of acetylcholinesterase. |
1(0,0,0,1) | Details |
| 10774652 | Karunaratne SH: Insecticide cross-resistance spectra and underlying resistance mechanisms of Sri Lankan anopheline vectors of malaria. Southeast Asian J Trop Med Public Health. 1999 Sep;30(3):460-9. Adult mosquitos were individually tested for their insecticide detoxifying enzyme activities and altered target-site, acetylcholinesterase. Adult and larval bioassays were carried out to obtain log-probit mortality lines for malathion, propoxur, permethrin and chlorpyrifos. |
1(0,0,0,1) | Details |
| 9768235 | Alvarez Montes de Oca DM, Ortiz Losada E, Bisset Lazcano JA, Rodriguez Coto MM: [Mechanisms of resistance to organophosphate insecticides, carbamates, and pyrethroids in populations of Musca domestica L. (Diptera: Muscidae)]. Rev Cubana Med Trop. 1994;46(1):51-4. Resistance to organophosphorus insecticides (malathion, chlorpyriphos, pyrimiphos-methyl); carbamates (propoxur); and pyrethroids (permethrin, deltametrine, cypermetrine, and lambda cialotrine) was studied in field populations of Musca domestica; results were compared with a susceptible reference strain. Biochemical microplate tests were also carried out to determine the presence of esterase and acetylcholinesterase enzymes in the three populations. |
1(0,0,0,1) | Details |
| 8551300 | Mazzarri MB, Georghiou GP: Characterization of resistance to organophosphate, and pyrethroid insecticides in field populations of Aedes aegypti from Venezuela. J Am Mosq Control Assoc. 1995 Sep;11(3):315-22. Resistance to chlorpyrifos (OP), permethrin, and lambda-cyhalothrin (pyrethroids) was moderate (7-fold) in both populations. |
0(0,0,0,0) | Details |
| 10480122 | Wirth MC, Georghiou GP: Selection and characterization of temephos resistance in a population of Aedes aegypti from Tortola, British Virgin Islands. J Am Mosq Control Assoc. 1999 Sep;15(3):315-20. Relatively low levels of resistance or cross-resistance to other organophosphate and insecticides, and a high level of resistance to the pyrethroid permethrin were also observed. |
0(0,0,0,0) | Details |
| 2132992 | Hemingway J, Callaghan A, Amin AM: Mechanisms of organophosphate and resistance in Culex quinquefasciatus from Saudi Arabia. Med Vet Entomol. 1990 Jul;4(3):275-82. There was a significant increase in the amount of Cytochrome P450 in Cx quinquefasciatus lines selected with the pyrethroid permethrin or with the organophosphate pirimiphos-methyl, but no change in lines selected with five other organophosphates or propoxur, compared to the parental strain, which suggests that oxidases are involved in the P450 mediated resistance to both permethrin and pirimiphos-methyl. |
0(0,0,0,0) | Details |
| 11248143 | Abou-Donia MB, Goldstein LB, Jones KH, Abdel-Rahman AA, Damodaran TV, Dechkovskaia AM, Bullman SL, Amir BE, Khan WA: Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. Toxicol Sci. 2001 Apr;60(2):305-14. Coexposure with PB, DEET, and permethrin resulted in significant inhibition in AChE in brainstem and midbrain. |
105(1,1,5,5) | Details |
| 14751452 | Abou-Donia MB, Dechkovskaia AM, Goldstein LB, Abdel-Rahman A, Bullman SL, Khan WA: Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity. Pharmacol Biochem Behav. 2004 Feb;77(2):253-62. Co-exposure to PB, DEET, and permethrin resulted in significant inhibition in AChE in midbrain. |
93(1,1,3,3) | Details |
| 7129545 | Bandyopadhyay R: Inhibition of acetylcholine esterase by permethrin & its reversion by acetylthiocholine. Indian J Exp Biol. 1982 Jun;20(6):488-91. |
81(1,1,1,1) | Details |
| 7595515 | Rao GV, Rao KS: Modulation in acetylcholinesterase of rat brain by pyrethroids in vivo and an in vitro kinetic study. J Neurochem. 1995 Nov;65(5):2259-66. The modulation of acetylcholinesterase (AChE) of rat brain by two pyrethroids--permethrin (PM) and cypermethrin (CPM)--was studied both in vivo and in vitro. |
33(0,1,1,3) | Details |