Protein Information

Name adenylate cyclase
Synonyms AH related protein; HCA2; ATP pyrophosphate lyase; Adenylate cyclase; Adenylyl cyclase soluble; HCA 2; RP1 313L4.2; SAC…

Compound Information

Name permethrin
CAS (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
2957417 Sahib IK, Prasada Rao KS, Desaiah D: Pyrethroid inhibition of basal and calmodulin stimulated Ca2+ ATPase and adenylate cyclase in rat brain. J Appl Toxicol. 1987 Apr;7(2):75-80.

None of the pyrethroids inhibited synaptosomal basal Ca2+ ATPase, but permethrin and deltamethrin inhibited basal adenylate cyclase in the nuclear fraction of a brain homogenate.
90(1,1,2,5) Details
2988554 Rashatwar SS, Matsumura F: Interaction of DDT and pyrethroids with calmodulin and its significance in the expression of enzyme activities of phosphodiesterase. Biochem Pharmacol. 1985 May 15;34(10):1689-94.

Permethrin was the most potent inhibitor affecting calmodulin and, to a lesser extent, phosphodiesterase.
These include modulation of phosphodiesterase, neurotransmitter release, adenylate cyclase, Ca2+-dependent protein kinase, myosine light chain kinase and various membrane phosphorylation systems.
1(0,0,0,1) Details