Protein Information

Name c fos
Synonyms Cellular oncogene fos; FBJ murine osteosarcoma viral (v fos) oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; c Fos…

Compound Information

Name permethrin
CAS (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
11082455 Imamura L, Hasegawa H, Kurashina K, Hamanishi A, Tabuchi A, Tsuda M: Repression of activity-dependent c-fos and brain-derived neurotrophic factor mRNA expression by pyrethroid insecticides accompanying a decrease in Ca (2+) influx into neurons. J Pharmacol Exp Ther. 2000 Dec;295(3):1175-82.

Immunoblotting analysis of c-Fos and a gel-mobility assay of AP-1 DNA-binding activity supported the decrease in c-Fos synthesis in permethrin-treated CGCs.
115(1,2,2,5) Details
15527870 Imamura L, Kurashina K, Kawahira T, Omoteno M, Tsuda M: Additional repression of activity-dependent c-fos and BDNF mRNA expression by lipophilic compounds accompanying a decrease in Ca2+ influx into neurons. Neurotoxicology. 2005 Jan;26(1):17-25.

In our previous study, we reported that permethrin and some other pyrethroid insecticides, which are suspected of being EDs, repressed the induction of c-fos and BDNF mRNA expression, accompanying a reduction of Ca2+ influx at doses non-toxic to CGCs.
32(0,1,1,2) Details
8856738 Hassouna I, Wickert H, el-Elaimy I, Zimmermann M, Herdegen T: Systemic application of pyrethroid insecticides evokes differential expression of c-Fos and c-Jun proteins in rat brain. Neurotoxicology. 1996 Summer;17(2):415-31.

Expression of the c-Fos and c-Jun transcription factor was investigated by immunocytochemistry in the thalamus, hypothalamus, hippocampus and cortex of adult rats following intraperitoneal application of proconvulsant doses of the pyrethroid insecticides, cypermethrin and permethrin.
15(0,0,2,5) Details
12111003 Imamura L, Hasegawa H, Kurashina K, Matsuno T, Tsuda M: Neonatal exposure of newborn mice to pyrethroid (permethrin) represses activity-dependent c-fos mRNA expression in cerebellum. Arch Toxicol. 2002 Jul;76(7):392-7. Epub 2002 May 29.
6(0,0,1,1) Details
19017407 Harrill JA, Li Z, Wright FA, Radio NM, Mundy WR, Tornero-Velez R, Crofton KM: Transcriptional response of rat frontal cortex following acute in vivo exposure to the pyrethroid insecticides permethrin and deltamethrin. BMC Genomics. 2008 Nov 18;9:546.

A sub-set of genes (Camk1g, Ddc, Gpd3, c-fos and Egr1) was then confirmed by qRT-PCR and examined in a time course study.
1(0,0,0,1) Details