| Name | androgen receptor |
|---|---|
| Synonyms | AIS; AR; Androgen receptor; DHTR; Dihydrotestosterone receptor; HUMARA; KD; NR3C4… |
| Name | permethrin |
|---|---|
| CAS | (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2325407 | Eil C, Nisula BC: The binding properties of pyrethroids to human skin fibroblast androgen receptors and to sex hormone binding globulin. J Steroid Biochem. 1990 Mar;35(3-4):409-14. All the pyrethroids tested inhibited fibroblast binding of [3H] methyltrienolone (R1881) at 22 degrees C with the following rank order of potency:pyrethrins greater than bioallethrin greater than fenvalerate greater than fenothrin greater than fluvalinate greater than permethrin greater than resmethrin. 50% displacement of [3H] R1881 binding to fibroblast androgen receptors was achieved by 1.5-44 x 10 (-5) M concentrations of the competitors, respectively. |
84(1,1,1,4) | Details |
| 16857237 | Sun H, Xu XL, Xu LC, Song L, Hong X, Chen JF, Cui LB, Wang XR: Antiandrogenic activity of pyrethroid pesticides and their metabolite in reporter gene assay. Chemosphere. 2007 Jan;66(3):474-9. Epub 2006 Jul 20. We tested three frequently encountered pyrethroids (fenvalerate, cypermethrin, permethrin) and their metabolite 3-phenoxybenzoic acid (3-PBA) for antiandrogenic and androgenic activity using a human androgen receptor (AR) mediated luciferase reporter gene assay in CV-1 African green monkey kidney cell. |
81(1,1,1,1) | Details |
| 12052007 | Kunimatsu T, Yamada T, Ose K, Sunami O, Kamita Y, Okuno Y, Seki T, Nakatsuka I: Lack of (anti-) androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays. Regul Toxicol Pharmacol. 2002 Apr;35(2 Pt 1):227-37. In the present study, we evaluated the interaction of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) with androgen receptor (AR)- and estrogen receptor (ER)-mediated mechanisms using in vivo short-term assays. |
81(1,1,1,1) | Details |
| 16621434 | Kim HJ, Park YI, Dong MS: Comparison of prostate cancer cell lines for androgen receptor-mediated reporter gene assays. Toxicol In Vitro. 2006 Oct;20(7):1159-67. Epub 2006 Mar 8. Permethrin inhibited the DHT induced luciferase activity about 22%, 35.8% and 75.5% in 22Rv1, PC3/AR (+) and LNCaP, respectively. |
2(0,0,0,2) | Details |
| 17980950 | Xu LC, Liu L, Ren XM, Zhang MR, Cong N, Xu AQ, Shao JH: Evaluation of androgen receptor transcriptional activities of some pesticides in vitro. Toxicology. 2008 Jan 14;243(1-2):59-65. Epub 2007 Oct 2. The selected chemicals are three organophosphate pesticides including dichlorvos, parathion and trichlorphon, and two pyrethroid pesticides including permethrin and cypermethrin. |
2(0,0,0,2) | Details |
| 18586453 | Zhang J, Zhu W, Zheng Y, Yang J, Zhu X: The antiandrogenic activity of pyrethroid pesticides cyfluthrin and beta-cyfluthrin. Reprod Toxicol. 2008 Aug;25(4):491-6. Epub 2008 May 15. A stably transfected, androgen-responsive cell line, MDA-kb2, was used to determine the androgen receptor (AR) antagonistic effects of cyfluthrin and beta-cyfluthrin in vitro, and the Hershberger assay was utilized to detect the antiandrogenic potential of the two pyrethroids in vivo. Moreover, we also compared the antiandrogenic activities of cyfluthrin and beta-cyfluthrin to four structurally related pyrethoids: permethrin, cypermethrin, beta-cypermethrin and bifenthrin. |
1(0,0,0,1) | Details |
| 11222871 | Tessier DM, Matsumura F: Increased ErbB-2 kinase activity, MAPK phosphorylation, and cell proliferation in the prostate cancer cell line LNCaP following treatment by select pesticides. Toxicol Sci. 2001 Mar;60(1):38-43. In the human prostate cancer cell lines LNCaP and PC-3, erbB-2 kinase was activated by pesticides of different chemical classes: (1) the organochlorine insecticides beta-hexa-chlorocyclohexane (beta-HCH), o,p'-dichlorodiphenyltrichloroethane (o,p'-DDT), and heptachlor epoxide; (2) the pyrethroid insecticide trans-permethrin, and (3) the fungicide chlorothalonil. o,p'-DDT also causes phosphorylation of mitogen-activated protein kinase (MAPK) and cellular proliferation of the androgen-dependent LNCaP line. |
0(0,0,0,0) | Details |