Protein Information

Name Cl 2
Synonyms AMB11; MHC class I NK cell receptor; CD158E1; CD158E1/2; CD158E2; CL 11; CL 2; HLA BW4 specific inhibitory NK cell receptor…

Compound Information

Name permethrin
CAS (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
12827372 Hardt J, Angerer J: Biological monitoring of workers after the application of insecticidal pyrethroids. Int Arch Occup Environ Health. 2003 Sep;76(7):492-8. Epub 2003 Jun 24.

METHODS: Thirty-six workers who applied insecticides and other pesticides in Germany collected samples of their urine (24 h) after having used various pyrethroids (alpha-cypermethrin, cypermethrin, cyfluthrin, deltamethrin, tau-fluvalinate, permethrin, lambda-cyhalothrin) in agriculture, greenhouses or indoor pest control.
Biological monitoring was carried out and metabolites were analysed in 61 urine samples by GC-MS: cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid ( cis-Cl (2) CA and trans-Cl (2) CA), cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid ( cis-Br (2) CA), 3-phenoxybenzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzoic acid (FPBA).
6(0,0,0,6) Details
18549292 Noort D, van Zuylen A, Fidder A, van Ommen B, Hulst AG: Protein adduct formation by glucuronide metabolites of permethrin. . Chem Res Toxicol. 2008 Jul;21(7):1396-406. Epub 2008 Jun 13.

Biomonitoring of exposure to the insecticide permethrin is usually performed by analysis of its urinary metabolites 3-phenoxybenzoic acid (3-PBA) or cis/ trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid (Cl 2 CA).
243(3,3,3,3) Details
11333180 Heudorf U, Angerer J: Metabolites of pyrethroid insecticides in urine specimens: current exposure in an urban population in Germany. Environ Health Perspect. 2001 Mar;109(3):213-7.

Accordingly, the levels of permethrin found in household dust from their homes were lower than expected (median < limit of detection; 95th percentile, 4.8 mg/kg; maximum value, 19 mg/kg).
Urine specimens were analyzed for cis-3-(2,2-dibromo-vinyl)-2,2-dimethylcyclo-propanecarboxylic acid (Br (2) CA), cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-carboxylic acid (cis-Cl (2) CA and trans-Cl (2) CA), and 4-fluoro-3-phenoxybenzoic acid (F-PBA) using a gas chromatographic method with mass-selective detection.
4(0,0,0,4) Details