Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name phenthoate
CAS ethyl α-[(dimethoxyphosphinothioyl)thio]benzeneacetate

Reference List

PubMed Abstract RScore(About this table)
6836603 Jash NB, Bhattacharya S: Phenthoate-induced changes in the profiles of acetylcholinesterase and acetylcholine in the brain of Anabas testudineus (Bloch): acute and delayed effect. Toxicol Lett. 1983 Mar;15(4):349-56.

Normal values for brain AChE activity and ACh concentration were restored only after 60 days following transfer to phenthoate-free fresh water.
124(1,2,4,4) Details
17024560 Wijeyaratne WM, Pathiratne A: Acetylcholinesterase inhibition and gill lesions in Rasbora caverii, an indigenous fish inhabiting rice field associated waterbodies in Sri Lanka. Ecotoxicology. 2006 Oct;15(7):609-19. Epub 2006 Oct 6.

Laboratory studies showed that prior exposure of R. caverii to Paraquat (2 microg l (-1), 7 days) enhanced the extent of inhibition of brain AChE activity induced by Fenthion (3 microg l (-1)) or a mixture of Fenthion (3 microg l (-1)) and Phenthoate (5 microg l (-1)).
40(0,1,2,5) Details
2496969 Rao KR, Rao KV: Combined action of carbaryl and phenthoate on the sensitivity of the acetylcholinesterase system of the fish, Channa punctatus (Bloch). Ecotoxicol Environ Saf. 1989 Feb;17(1):12-5.

Inhibition of acetylcholinesterase (AChE) and accumulation of acetylcholine were observed in tissues of fish, Channa punctatus, during carbaryl and/or phenthoate toxicity.
68(0,2,3,3) Details
15683842 Park KH, Kim YS, Chung EY, Choe SN, Choo JJ: Cardiac responses of Pacific oyster Crassostrea gigas to agents modulating cholinergic function. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Dec;139(4):303-8.

While other reversible AChE inhibitors such neostigmine and pyridostigmine also depressed the contractility, organophosphate AChE inhibitors malathion, diazinon, or phenthoate did not.
34(0,1,1,4) Details
3268109 Guhathakurta S, Bhattacharya S: Target and nontarget actions of phenthoate and carbofuran: brain acetylcholinesterase, kidney iodide peroxidase, and blood thyroxine profiles in Channa punctatus. Biomed Environ Sci. 1988 Jun;1(1):59-63.

These xenobiotics caused significant inhibition of brain acetylcholinesterase concomitant with low kidney iodide peroxidase activity and depressed blood thyroxine levels.
1(0,0,0,1) Details