Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name phosalone
CAS

Reference List

PubMed Abstract RScore(About this table)
16440853 Bharavi K, Reddy KS: Effect of anticholinesterase compound phosalone on blood-brain barrier (BBB) permeability. Indian J Physiol Pharmacol. 2005 Jul-Sep;49(3):337-40.

To elucidate the role of acetylcholinesterase (AChE) enzyme in BBB function, phosalone, an organophosphorous compound, was studied using rat brain micro vessels in vitro.
163(2,2,2,3) Details
9294250 Scaps P, Demuynck S, Descamps M, Dhainaut A: Effects of organophosphate and carbamate pesticides on acetylcholinesterase and choline acetyltransferase activities of the polychaete Nereis diversicolor. Arch Environ Contam Toxicol. 1997 Aug;33(2):203-8.

On the other hand, inhibitory effects on acetylcholinesterase (AChE) activity were determined at concentrations of 10 (-6) M for three OP compounds-malathion, parathion-ethyl, and phosalone-and a carbamate pesticide-carbaryl.
32(0,1,1,2) Details
1769726 Devaraj P, Selvarajan VR, Durairaj S: Relationship between acetylcholinesterase and monoamine oxidase in brain regions of Oreochromis mossambicus exposed to phosalone. Indian J Exp Biol. 1991 Aug;29(8):790-2.
14(0,0,2,4) Details
1778118 Bocquene G, Galgani F: Acetylcholinesterase activity in the common prawn (Palaemon serratus) contaminated by carbaryl and phosalone: choice of a method for detection of effects. Ecotoxicol Environ Saf. 1991 Dec;22(3):337-44.
7(0,0,1,2) Details
7726573 Lai K, Stolowich NJ, Wild JR: Characterization of P-S bond hydrolysis in organophosphorothioate pesticides by organophosphorus hydrolase. Arch Biochem Biophys. 1995 Apr 1;318(1):59-64.


The extensive use of organophosphorothioate insecticides in agriculture has resulted in the risk of environmental contamination with a variety of broadly based neurotoxins that inhibit the acetylcholinesterases of many different animal species.
2(0,0,0,2) Details
8343988 Vasilic Z, Drevenkar V, Stengl B, Frobe Z, Rumenjak V: Diethylphosphorus metabolites in serum and urine of persons poisoned by phosalone. Chem Biol Interact. 1993 Jun;87(1-3):305-13.

The correlation between the maximum concentrations of total metabolites, measured in urine of poisoned persons on the day of admission to hospital or a day later, and the initial depression of serum cholinesterase (EC 3.1.1.8) and erythrocyte acetylcholinesterase (EC 3.1.1.7) activities was poor (r = 0.6).
1(0,0,0,1) Details
2402003 Balasundaram K, Selvarajan VR: Inhibition of acetylcholinesterase in the central nervous system of Rana tigrina by an organophosphate. J Biochem Toxicol. 1990 Spring;5(1):65-6.

1(0,0,0,1) Details