| Name | Cytochrome c oxidase (protein family or complex) |
|---|---|
| Synonyms | COX; cytochrome c oxidase; cytochrome c oxidases |
| Name | phosphine |
|---|---|
| CAS | phosphine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19280425 | Proudfoot AT: Aluminium and zinc phosphide poisoning. Clin Toxicol. 2009 Feb;47(2):89-100. MECHANISMS OF TOXICITY: Both forms of poisoning are mediated by phosphine which has been thought to be toxic because it inhibits cytochrome c oxidase. |
163(2,2,2,3) | Details |
| 15727053 | Sudakin DL: Occupational exposure to aluminium phosphide and phosphine gas? A suspected case report and review of the literature. Hum Exp Toxicol. 2005 Jan;24(1):27-33. Toxicodynamic effects of phosphine result from the inhibition of cytochrome c oxidase and subsequent generation of reactive species. |
81(1,1,1,1) | Details |
| 18755236 | Valmas N, Zuryn S, Ebert PR: Mitochondrial uncouplers act synergistically with the fumigant phosphine to disrupt mitochondrial membrane potential and cause cell death. Toxicology. 2008 Oct 30;252(1-3):33-9. Epub 2008 Aug 5. As phosphine inhibits cytochrome c oxidase (complex IV) of the mitochondrial respiratory chain and reduces the strength of the mitochondrial membrane potential (DeltaPsi (m)), we reasoned that mitochondrial uncouplers should act synergistically with phosphine. |
81(1,1,1,1) | Details |
| 16615671 | Singh S, Bhalla A, Verma SK, Kaur A, Gill K: Cytochrome-c oxidase inhibition in 26 aluminum phosphide poisoned patients. Clin Toxicol. 2006;44(2):155-8. In the presence of moisture, ALP liberates phosphine, which is highly toxic. |
3(0,0,0,3) | Details |
| 16363808 | Imriskova-Sosova I, Andrews D, Yam K, Davidson D, Yachnin B, Hill BC: Characterization of the redox and metal binding activity of BsSco, a protein implicated in the assembly of cytochrome c oxidase. Biochemistry. 2005 Dec 27;44(51):16949-56. |
2(0,0,0,2) | Details |
| 18298114 | Harkins SB, Mankad NP, Miller AJ, Szilagyi RK, Peters JC: Probing the electronic structures of [Cu2 (mu-XR2)] n+ diamond cores as a function of the bridging X atom (X = N or P) and charge (n = 0, 1, 2). J Am Chem Soc. 2008 Mar 19;130(11):3478-85. Epub 2008 Feb 26. These dicopper complexes feature terminal phosphine and either bridging amido or phosphido donors, and as such their metal-ligand bonds are highly covalent. The electronic structure picture that emerges for these inorganic dicopper diamond cores shares similarities with the Cu2 (mu-SR) 2 CuA sites of cytochrome c oxidases and nitrous oxide reductases. |
1(0,0,0,1) | Details |