| 15256702 |
Seto M, Aramaki Y, Imoto H, Aikawa K, Oda T, Kanzaki N, Iizawa Y, Baba M, Shiraishi M: Orally active CCR5 antagonists as anti-HIV-1 agents 2: synthesis and biological activities of anilide derivatives containing a pyridine N-oxide moiety. Chem Pharm Bull. 2004 Jul;52(7):818-29.
In order to develop orally active CCR5 antagonists, we investigated 1-benzoxepine derivatives containing new polar substituents, such as phosphonate, phosphine oxide or pyridine N-oxide moieties, as replacements for the previously reported quaternary ammonium moiety. |
34(0,1,1,4) |
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