Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name prochloraz
CAS

Reference List

PubMed Abstract RScore(About this table)
2756713 Bach J, Snegaroff J: Effects of the fungicide prochloraz on xenobiotic metabolism in rainbow trout: in vivo induction. Xenobiotica. 1989 Jan;19(1):1-9.

Glutathione-S-transferase (o-dinitrobenzene as substrate), was unchanged or inhibited by prochloraz. 6.
81(1,1,1,1) Details
18161575 Sanchez W, Piccini B, Porcher JM: Effect of prochloraz fungicide on biotransformation enzymes and oxidative stress parameters in three-spined stickleback (Gasterosteus aculeatus L.). J Environ Sci Health B. 2008 Jan;43(1):65-70.

At days 7, 14 and 21, several hepatic biomarkers were measured including 7-ethoxyresorufin-O-deethylase (EROD), glutathione-S-transferase (GST), glutathione peroxidase (GPx), catalase (CAT), total glutathione (GSH) content and thiobarbituric acid reactive substances (TBARS).
1(0,0,0,1) Details
1862543 Cabral R, Hoshiya T, Hakoi K, Hasegawa R, Fukushima S, Ito N: A rapid in vivo bioassay for the carcinogenicity of pesticides. Tumori. 1991 Jun 30;77(3):185-8.

Hepatocarcinogenic potential was assessed by comparing the number and area of glutathione s-transferase (placental form) -positive foci in the liver with those of controls given diethylnitrosamine alone.
Positive results were seen with Chinomethionat, Phosmet and Propiconazole; the results obtained with Captan and Prochloraz were borderline; Benomyl, Daminozide and Folpet gave negative results.
1(0,0,0,1) Details