| Name | CYP51 |
|---|---|
| Synonyms | CP51; CYPL 1; CYPL1; CYP51; CYP51A1; CYPLI; Cytochrome P450 51A1; LDM… |
| Name | prochloraz |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16330141 | Trosken ER, Fischer K, Volkel W, Lutz WK: Inhibition of human CYP19 by azoles used as antifungal agents and aromatase inhibitors, using a new LC-MS/MS method for the analysis of product formation. Toxicology. 2006 Feb 15;219(1-3):33-40. Epub 2005 Dec 5. However, azoles used as fungicides, e.g. prochloraz, or as antifungal drugs, e.g. bifonazole, were almost as potent inhibitors of aromatase as the drugs used in tumor therapy. Their therapeutic activity is based on the inhibition of fungal -14alpha-demethylase (CYP51). |
1(0,0,0,1) | Details |
| 11055899 | Dyer PS, Hansen J, Delaney, Lucas JA: Genetic control of resistance to the sterol 14alpha-demethylase inhibitor fungicide prochloraz in the cereal eyespot pathogen Tapesia yallundae. Appl Environ Microbiol. 2000 Nov;66(11):4599-604. Sexual crosses were used to determine the genetic basis of resistance to the sterol 14 alpha-demethylase inhibitor fungicide prochloraz in the cereal eyespot pathogen Tapesia yallundae. |
31(0,1,1,1) | Details |
| 11267777 | Wood HM, Dickinson MJ, Lucas JA, Dyer PS: Cloning of the CYP51 gene from the eyespot pathogen Tapesia yallundae indicates that resistance to the DMI fungicide prochloraz is not related to sequence changes in the gene encoding the target site enzyme. FEMS Microbiol Lett. 2001 Mar 15;196(2):183-7. CYP51 was sequenced from four field isolates sensitive or resistant to the DMI fungicide prochloraz and partially sequenced from two further isolates and eight progeny from a cross between prochloraz-sensitive and -resistant parents. |
9(0,0,1,4) | Details |
| 17511023 | Leroux P, Albertini C, Gautier A, Gredt M, Walker AS: Mutations in the CYP51 gene correlated with changes in sensitivity to sterol 14 alpha-demethylation inhibitors in field isolates of Mycosphaerella graminicola. Pest Manag Sci. 2007 Jul;63(7):688-98. In four of them, cross-resistance was not observed between all tested DMIs; this characteristic concerned prochloraz, triflumizole, fluquinconazole and tebuconazole. |
2(0,0,0,2) | Details |
| 15554355 | Trosken ER, Scholz K, Lutz RW, Volkel W, Zarn JA, Lutz WK: Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans. Endocr Res. 2004 Aug;30(3):387-94. Antifungal activity is based on inhibition of fungal CYP51 14alpha-demethylase), and biosynthesis reduction is due to azole inhibition of CYP19 (aromatase). Most potent fungicides included prochloraz, flusilazole, and imazalil, and most potent medicinal antifungals were bifonazole, miconazole, and |
1(0,0,0,1) | Details |