| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | prochloraz |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2501938 | Snegaroff J, Bach J: Effects of the fungicide prochloraz on xenobiotic metabolism in rainbow trout: inhibition in vitro and time course of induction in vivo. Xenobiotica. 1989 Mar;19(3):255-67. Interactions between the fungicide prochloraz and the hepatic cytochrome P-450 of rainbow trout were studied by determination of enzymic activities in vitro using the microsomal fraction, and by kinetic studies. 2. |
82(1,1,1,2) | Details |
| 1949900 | Antignac E, Koch B, Delaforge M, Narbonne JF: In vitro effects of an antifungal, prochloraz, on spectral and catalytic properties of microsomal cytochromes P-450. Xenobiotica. 1991 May;21(5):669-78. Prochloraz is a strong inhibitor of the cytochrome P-450-dependent mixed-function oxidases in rat liver microsomal preparations. |
82(1,1,1,2) | Details |
| 19767443 | Ankley GT, Bencic DC, Cavallin JE, Jensen KM, Kahl MD, Makynen EA, Martinovic D, Mueller ND, Wehmas LC, Villeneuve DL: Dynamic nature of alterations in the endocrine system of fathead minnows exposed to the fungicide prochloraz. Toxicol Sci. 2009 Dec;112(2):344-53. Epub 2009 Sep 18. Consistent with one mechanism of action of prochloraz, inhibition of cytochrome P450 (CYP) 19 aromatase activity, the fungicide depressed ex vivo ovarian production and plasma concentrations of 17beta- (E2) in female fish. |
81(1,1,1,1) | Details |
| 15788727 | Vinggaard AM, Christiansen S, Laier P, Poulsen ME, Breinholt V, Jarfelt K, Jacobsen H, Dalgaard M, Nellemann C, Hass U: Perinatal exposure to the fungicide prochloraz feminizes the male rat offspring. Toxicol Sci. 2005 Jun;85(2):886-97. Epub 2005 Mar 23. In addition cytochrome P450 (CYP) 1A activities in livers were induced by prochloraz, possibly as a result of Ah receptor activation. |
31(0,1,1,1) | Details |
| 7481747 | Johnston G: The study of interactive effects of pollutants: a biomarker approach. Sci Total Environ. 1995 Oct 27;171(1-3):205-12. The mechanism of increased activation of malathion due to induction of cytochrome P-450 by prochloraz is reviewed. |
31(0,1,1,1) | Details |
| 2756713 | Bach J, Snegaroff J: Effects of the fungicide prochloraz on xenobiotic metabolism in rainbow trout: in vivo induction. Xenobiotica. 1989 Jan;19(1):1-9. Prochloraz increased cytochrome P-450 in liver, intestine, and pyloric caeca: maximum response occurred at 30-100 mg/kg i.p. |
7(0,0,1,2) | Details |
| 15091443 | Johnston G, Dawson A, Walker CH: Effects of prochloraz and malathion on the red-legged partridge: a semi-natural field study. Environ Pollut. 1996;91(2):217-25. Cytochrome P-450, aldrin epoxidase and 7-ethoxyresorufin-O-deethylase (EROD) activities were found to be significantly higher in the group exposed to prochloraz alone compared to controls, suggesting that induction of the hepatic microsomal monooxygenase system had occurred by ingestion of prochloraz-treated wheat. |
6(0,0,1,1) | Details |
| 2683412 | Walker CH, Ronis MJ: The monooxygenases of birds, reptiles and amphibians. Xenobiotica. 1989 Oct;19(10):1111-21. Microsomal monooxygenase systems which contain cytochrome P-450 forms as their active centres are found in birds, reptiles and amphibians. Prochloraz is a stronger inducer in birds than in the rat; it is an inducer of mixed type in birds. 5. |
2(0,0,0,2) | Details |
| 18835618 | Takeuchi S, Iida M, Yabushita H, Matsuda T, Kojima H: In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides using a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-1A induction by propanil, diuron and linuron. Chemosphere. 2008 Dec;74(1):155-65. Epub 2008 Oct 5. Eleven of the 200 pesticides (acifluorfen-methyl, bifenox, chlorpyrifos, isoxathion, quinalphos, chlorpropham, diethofencarb, propanil, diuron, linuron, and prochloraz) showed AhR-mediated transcriptional activity. |
2(0,0,0,2) | Details |
| 1685398 | Borlakoglu JT, Stegeman J, Dils RR: Induction of hepatic cytochrome P-450IA1 in pigeons treated in vivo with Aroclor 1254, a commercial mixture of polychlorinated biphenyls (PCBs). Comp Biochem Physiol C. 1991;99(3):279-86. It is concluded that treatment with a commercial PCB mixture resulted in the induction of several isoforms of pigeon hepatic cytochrome P-450 in a fashion that is likely to be similar to that reported for mammals. |
1(0,0,0,1) | Details |
| 2631296 | Laignelet L, Narbonne JF, Lhuguenot JC, Riviere JL: Induction and inhibition of rat liver cytochrome (s) P-450 by an fungicide (prochloraz). Toxicology. 1989 Dec 15;59(3):271-84. When animals were sacrificed 24 h after the last dose, an increase in total cytochrome P-450 was observed as well as an increase in catalytic activities towards benzphetamine, alkoxyresorufins and alkoxycoumarins. |
1(0,0,0,1) | Details |
| 18800561 | Zhang X, Hecker M, Tompsett AR, Park JW, Jones PD, Newsted J, Au D, Kong R, Wu RS, Giesy JP: Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole. Environ Sci Technol. 2008 Sep 1;42(17):6762-9. Exposure to PCZ caused a compensatory upregulation in cytochrome P450 c17alphahydroxylase, 17,20-lyase (CYP17) and aromatase (CYP19) expression in the ovary, while KTC did not. |
1(0,0,0,1) | Details |
| 9626537 | Walker CH: The use of biomarkers to measure the interactive effects of chemicals. Ecotoxicol Environ Saf. 1998 May-Jun;40(1-2):65-70. The interactive effects of mixtures of pesticides in the field are starting to be investigated by this approach (e.g., a recent study of the combined action of malathion and prochloraz in the red-legged partridge). Assays for DNA damage can indicate where there is an increase in the rate of activation of carcinogens and mutagens due to induction of the cytochrome P450 system. |
1(0,0,0,1) | Details |
| 9972473 | Amichot M, Brun A, Cuany A, De Souza G, Le Mouel T, Bride JM, Babault M, Salaun JP, Rahmani R, Berge JB: Induction of cytochrome P450 activities in Drosophila melanogaster strains susceptible or resistant to insecticides. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):311-9. In addition, we also treated the flies with eight chemicals (beta-naphtoflavone, benzo-alpha-pyrene, 3-methylcholanthrene, phenobarbital, aminopyrine, rifampicin, prochloraz, and clofibrate) known to induces genes from the families CYP1, CYP2, CYP3, CYP4, and CYP6. |
1(0,0,0,1) | Details |
| 9972451 | Walker CH: Avian forms of cytochrome P450. . Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):65-72. Fungicides which act as biosynthesis inhibitors (EBI fungicides) such as prochloraz and propiconazole potentiate the toxicity of certain phosphorothionates to birds. |
1(0,0,0,1) | Details |