| Name | deoxyhypusine synthase |
|---|---|
| Synonyms | DHS; DHS; Deoxyhypusine synthase; synthase, deoxyhypusine |
| Name | butylamine |
|---|---|
| CAS | 2-butanamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11104695 | Lee CH, Park MH: Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates. Biochem J. 2000 Dec 15;352 Pt 3:851-7. Deoxyhypusine synthase catalyses the NAD-dependent transfer of the butylamine moiety from the polyamine, to a specific residue of a single cellular protein, eukaryotic translation-initiation factor 5A (eIF5A) precursor. |
82(1,1,1,2) | Details |
| 10630376 | Kang KR, Chung SI: Characterization of yeast deoxyhypusine synthase: PKC-dependent phosphorylation in vitro and functional domain identification. Exp Mol Med. 1999 Dec 31;31(4):210-6. The biosynthesis of hypusine [Nepsilon-(4-amino-2-hydroxybutyl)- occurs in the eIF-5A precursor protein through two step posttranslational modification involving deoxyhypusine synthase which catalyzes transfer of the butylamine moiety of to the epsilon-amino group of a designated residue and subsequent hydroxylation of this intermediate. |
35(0,1,1,5) | Details |
| 9188485 | Wolff EC, Folk JE, Park MH: Enzyme-substrate intermediate formation at 329 of human deoxyhypusine synthase. J Biol Chem. 1997 Jun 20;272(25):15865-71. Deoxyhypusine synthase catalyzes the formation of deoxyhypusine by conjugation of the butylamine moiety of to the epsilon-amino group of one specific residue of the eukaryotic translation initiation factor 5A (eIF-5A) precursor protein. |
82(1,1,1,2) | Details |
| 14749535 | Kang KR, Chung SI: Protein kinase CK2 phosphorylates and interacts with deoxyhypusine synthase in HeLa cells. Exp Mol Med. 2003 Dec 31;35(6):556-64. Deoxyhypusine is a modified and formed posttranslationally to be the eukaryotic initiation factor eIF5A by deoxyhypusine synthase, employing as butylamine donor. |
39(0,1,1,9) | Details |
| 10734052 | Wolff EC, Wolff J, Park MH: Deoxyhypusine synthase generates and uses bound in a transient hydride transfer mechanism. J Biol Chem. 2000 Mar 31;275(13):9170-7. It is formed posttranslationally in the precursor of eukaryotic initiation factor 5A (eIF5A) by deoxyhypusine synthase, employing as a butylamine donor. |
8(0,0,1,3) | Details |
| 7721768 | Wolff EC, Lee YB, Chung SI, Folk JE, Park MH: Deoxyhypusine synthase from rat testis: purification and characterization. J Biol Chem. 1995 Apr 14;270(15):8660-6. This NAD-dependent enzyme catalyzes the formation of deoxyhypusine by transfer of the butylamine portion of to the epsilon-amino group of a specific residue in the eIF-5A precursor. |
4(0,0,0,4) | Details |