| Name | Potassium channel (protein family or complex) |
|---|---|
| Synonyms | Potassium channel |
| Name | butylamine |
|---|---|
| CAS | 2-butanamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15312756 | Chen YP, Qiu CR, Wang H: Cardiovascular pharmacological characterization of novel 2,3-dimethyl-2-butylamine derivatives in rats. Life Sci. 2004 Sep 10;75(17):2131-42. Collectively, these results indicate that 2,3-dimethyl-2-butylamine derivatives, which differ chemically from previously described potassium channel openers, have potassium channel opening activity, hypotensive and cardiac-modulating properties that depend on their amino group substituents. |
81(1,1,1,1) | Details |
| 17266574 | Wang H, Tang Y, Wang L, Long CL, Zhang YL: ATP-sensitive potassium channel openers and 2,3-dimethyl-2-butylamine derivatives. Curr Med Chem. 2007;14(2):133-55. |
32(0,1,1,2) | Details |
| 16614730 | Wang H, Tang Y, Zhang YL: Hypoxic pulmonary hypertension (HPH) and iptakalim, a novel ATP-sensitive potassium channel opener targeting smaller arteries in hypertension. Cardiovasc Drug Rev. 2005 Winter;23(4):293-316. Iptakalim (2,3-dimethyl-N-(1-methylethyl)-2-butylamine), a novel ATP-sensitive potassium channel opener, has the desired effects on hypoxic pulmonary arteries. |
8(0,0,1,3) | Details |
| 7894673 | Nieto C, Ramis J, Conte L, Fernandez JM, Forn J: On-line fully automated solid-phase extraction-liquid chromatography analysis of 1,2-dihydro-4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethyl-1-oxonaphthale ne-6- carbonitrile (UR-8225), a new potassium channel opener, in plasma samples. J Chromatogr B Biomed Appl. 1994 Nov 18;661(2):319-25. After clean up, the samples were eluted and transferred onto an RP-18 analytical column, where separation was performed with a mobile phase of acetonitrile-10 mM di-n-butylamine (28:72, v/v). |
2(0,0,0,2) | Details |
| 15525792 | Wang H, Long CL, Zhang YL: A new ATP-sensitive potassium channel opener reduces blood pressure and reverses cardiovascular remodeling in experimental hypertension. J Pharmacol Exp Ther. 2005 Mar;312(3):1326-33. Epub 2004 Nov 3. Iptakalim [2,3-dimethyl-n-(1-methylethyl)-2-butylamine], which belongs to a novel chemical type of KCO, possesses unique pharmacological characteristics. |
2(0,0,0,2) | Details |