| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | butylamine |
|---|---|
| CAS | 2-butanamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1855867 | Ludeke B, Meier T, Kleihues P: Bioactivation of asymmetric N-dialkylnitrosamines in rat tissues derived from the ventral entoderm. IARC Sci Publ. 1991;(105):286-93. In order to determine whether more than one cytochrome P450 isozyme is involved in the bioactivation of asymmetrical aliphatic dialkylnitrosamines in these tissues, we have studied the effects of various modulators of nitrosamine metabolism, including dietary zinc deficiency, and disulfiram, on DNA alkylation by N-nitrosomethyl-n-butylamine (NMBA) and its ethyl analogue N-nitrosoethyl-n-butylamine (NEBA). |
31(0,1,1,1) | Details |
| 2924300 | Lee M, Ishizaki H, Brady JF, Yang CS: Substrate specificity and alkyl group selectivity in the metabolism of N-nitrosodialkylamines. Cancer Res. 1989 Mar 15;49(6):1470-4. In previous work, we characterized P450IIE1 (an /-inducible form of cytochrome P-450) as the major enzyme for the metabolic activation of N-nitrosodimethylamine. |
3(0,0,0,3) | Details |
| 3754494 | Appel KE, Wiessler M, Schoepke M, Ruhl CS, Hildebrandt AG: Metabolic formation from N-nitrosamines: are there other pathways than reductive denitrosation by cytochrome P-450?. Carcinogenesis. 1986 Apr;7(4):659-63. |
3(0,0,0,3) | Details |
| 8495399 | Huang Q, Wang S, Chen SC, Babcook DM, Park SS, Gelboin HV, Mirvish SS: Hydroxylation and dealkylation of methyl-n-butylnitrosamine and role of certain cytochrome P-450 isozymes in these reactions. Cancer Lett. 1993 Apr 30;69(2):107-16. |
2(0,0,0,2) | Details |
| 3433799 | Lindeke B, Ericsson O, Jonsson A, Noren B, Stromberg S, Vangbo B: Biotransformation of terodiline. Xenobiotica. 1987 Nov;17(11):1269-78. The results from the study are compatible with the participation of multiple forms of cytochrome P-450 enzymes. Terodiline (N-tert-butyl-4,4-diphenyl-2-butylamine) is a racemic drug with anticholinergic and/or antagonistic activity, which is subject to renewed interest as a potential remedy for urinary incontinence. |
1(0,0,0,1) | Details |
| 6667456 | Kawanishi T, Ohno Y, Takahashi A, Nakadate M, Takanaka A, Kasuya Y, Omori Y: Effect of phenobarbital and 3-methylcholanthrene on the hepatic microsomal metabolism of N-nitrosodimethylamine, N-nitrosomethylbutylamine and N-nitrosomethylbenzylamine. Cancer Lett. 1983 Sep;20(2):157-64. These results suggest that the dealkylations of these nitrosamines are catalyzed by several enzymes, which probably depend on different cytochrome P-450 species. |
1(0,0,0,1) | Details |
| 6533047 | Janzowski C, Eisenbrand G, Gottfried J, Preussmann R: Effects of fluorination on in-vitro metabolism and biological activity of N-nitrosodialkylamines. IARC Sci Publ. 1984;(57):553-8. The results of in-vitro metabolism studies with N-nitrosodiethylamine (NDEA), N-nitrosodibutylamine (NDBA) and their fluorinated analogues, N-nitroso-2,2,2-trifluoroethyl-ethylamine (NDEA-F3), N-nitroso-bis (2,2,2-trifluoroethyl) amine (NDEA-F6), N-nitroso-4,4,4-trifluorobutyl-butylamine (NDBA-F3), N-nitroso-bis (4,4,4-trifluo-robutyl) amine (NDBA-F6) and N-nitroso-bis (2,2,3,3,4,4,4-heptafluorobutyl) amine (NDBA-F14), showed effects of fluorination on biotransformation which can explain results of carcinogenicity and mutagenicity experiments; NDEA-F6 and NDBA-F14 were practically not metabolized by microsomal fractions, even though no decrease in binding affinity to cytochrome P450 was observed. |
0(0,0,0,0) | Details |