| Name | ubiquitin |
|---|---|
| Synonyms | HMG20; RPS27A; UBA80; UBCEP 1; UBCEP1; UBA52; UBCEP 2; UBCEP2… |
| Name | butylamine |
|---|---|
| CAS | 2-butanamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15708793 | Nguewa PA, Fuertes MA, Iborra S, Najajreh Y, Gibson D, Martinez E, Alonso C, Perez JM: soluble cationic trans-platinum complexes which induce programmed cell death in the protozoan parasite Leishmania infantum. J Inorg Biochem. 2005 Mar;99(3):727-36. Epub 2005 Jan 1. We have evaluated the cytotoxic properties against the protozoan Leishmania infantum of four water soluble cationic trans-Pt (II) Cl (2) compounds containing as inert groups NH3 and piperazine (1), 4-picoline and piperazine (2), n-butylamine and piperazine (3), and NH3 and 4-piperidino-piperidine (4). Similarly to cis-diamminedichloroplatinum (II) and trans-diamminedichloroplatinum (II), the interaction of compounds 3 and 4 with ubiquitin results in an increase of the alpha-helix content of the protein as observed by circular dichroism spectroscopy. |
2(0,0,0,2) | Details |
| 12431046 | Najajreh Y, Perez JM, Navarro-Ranninger C, Gibson D: Novel soluble cationic trans-diaminedichloroplatinum (II) complexes that are active against cisplatin resistant ovarian cancer cell lines. J Med Chem. 2002 Nov 21;45(24):5189-95. Positively charged, water soluble cis/trans-[PtCl (2)(piperazine)(Am1)] (where Am1 = NH (3), n-butylamine, isopropylamine, 4-picoline, piperidine, and piperazine) has significant cytotoxic activity against cisplatin resistant ovarian cancer cells. The platinum-piperazine complexes bind proteins (ubiquitin and myoglobin) very slowly as compared to cisplatin and to their neutral piperidine analogues. |
1(0,0,0,1) | Details |
| 16854073 | Najajreh Y, Ardeli-Tzaraf Y, Kasparkova J, Heringova P, Prilutski D, Balter L, Jawbry S, Khazanov E, Perez JM, Barenholz Y, Brabec V, Gibson D: Interactions of platinum complexes containing cationic, bicyclic, nonplanar piperidinopiperidine ligands with biological nucleophiles. J Med Chem. 2006 Jul 27;49(15):4674-83. The determination of the structures and DNA interactions and the reactions with GSH and ubiquitin of complexes of the general formula trans-[PtCl2 (Am)(pip-pip)] x HCl, where pip-pip is 4-piperidinopiperidine and Am is NH3, (MA), (DMA), n-propylamine (NPA), isopropylamine (IPA), n-butylamine (NBA), or cyclohexylamine (CHA), were performed. |
33(0,1,1,3) | Details |