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Taniguchi K, Okumura K, Take K, Tsubaki K, Terai T, Nakanishi I, Shiokawa Y: Agents for the treatment of overactive detrusor. Chem Pharm Bull. 1995 Jan;43(1):71-7.
The order of inhibitory activity (i.v.) of the N-tert-butylamine derivatives against urinary bladder rhythmic contraction in rats was as follows: S (-)-4,4-diphenyl-2-cyclopentenylamine (FK584, S (-)-3a) > 4,4-diphenylcyclohexylamine (5b) = R (-)-3,3-diphenylcyclopentylamine (R (-)-4) > or = 3,3-diphenylcyclobutylamine (2) > or = terodiline hydrochloride (HCl) (1) = RS (+/-)-4,4-diphenyl-2-cyclohexenylamine (5a) > R (+)-4,4-diphenyl-2-cyclopentenylamine (R (+)-3a) > or = S (+)-3,3-diphenylcyclopentylamine (S (+)-4). |
31(0,1,1,1) |
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