| 17116678 |
Roberts SC, Jiang Y, Gasteier J, Frydman B, Marton LJ, Heby O, Ullman B: Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs. Antimicrob Agents Chemother. 2007 Feb;51(2):438-45. Epub 2006 Nov 20.
The ODC, ADOMETDC, and SPDSYN overproducer strains exhibited a high level of resistance to difluoromethylornithine, 5'-{[(Z)-4-amino-2-butenyl] methylamino}-5'-deoxyadenosine, and n-butylamine, respectively, confirming previous observations that these agents specifically target polyamine enzymes. |
32(0,1,1,2) |
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