Protein Information

Name ornithine decarboxylase
Synonyms ODC; ODC 1; ODC 2; ODC1; ODC1 protein; ODC2; ODCP; Ornithine decarboxylase…

Compound Information

Name cacodylic acid
CAS dimethylarsinic acid

Reference List

PubMed Abstract RScore(About this table)
10874208 Morikawa T, Wanibuchi H, Morimura K, Ogawa M, Fukushima S: Promotion of skin carcinogenesis by dimethylarsinic acid in keratin (K6)/ODC transgenic mice. Jpn J Cancer Res. 2000 Jun;91(6):579-81.


Transgenic mice with ornithine decarboxylase (ODC) targeted to hair follicle keratinocytes are much more sensitive than littermate controls to carcinogens.
1(0,0,0,1) Details
7882321 Yamamoto S, Konishi Y, Matsuda T, Murai T, Shibata MA, Matsui-Yuasa I, Otani S, Kuroda K, Endo G, Fukushima S: Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens. Cancer Res. 1995 Mar 15;55(6):1271-6.

Ornithine decarboxylase activity in the kidneys of rats treated with 100 ppm DMA was significantly increased compared with control values (P < 0.001).
1(0,0,0,1) Details
9473732 Wanibuchi H, Hori T, Meenakshi V, Ichihara T, Yamamoto S, Yano Y, Otani S, Nakae D, Konishi Y, Fukushima S: Promotion of rat hepatocarcinogenesis by dimethylarsinic acid: association with elevated ornithine decarboxylase activity and formation of 8-hydroxydeoxyguanosine in the liver. Jpn J Cancer Res. 1997 Dec;88(12):1149-54.

2(0,0,0,2) Details
9219572 Yamamoto S, Wanibuchi H, Hori T, Yano Y, Matsui-Yuasa I, Otani S, Chen H, Yoshida K, Kuroda K, Endo G, Fukushima S: Possible carcinogenic potential of dimethylarsinic acid as assessed in rat in vivo models: a review. Mutat Res. 1997 Jun;386(3):353-61.


This was associated with significantly elevated ornithine decarboxylase activity in the kidneys of DMA-treated animals.
1(0,0,0,1) Details