Protein Information

Name caspase (protein family or complex)
Synonyms caspase; caspases

Compound Information

Name cacodylic acid
CAS dimethylarsinic acid

Reference List

PubMed Abstract RScore(About this table)
11446828 Namgung U, Xia Z: Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. Toxicol Appl Pharmacol. 2001 Jul 15;174(2):130-8.


Cotreatment with cycloheximide or actinomycin D, inhibitors of protein or RNA synthesis, respectively, or with the caspase inhibitor zVAD, completely blocked arsenite-induced cerebellar neuron apoptosis.
2(0,0,0,2) Details
15276415 Sakurai T, Ochiai M, Kojima C, Ohta T, Sakurai MH, Takada NO, Qu W, Waalkes MP, Fujiwara K: Role of glutathione in dimethylarsinic acid-induced apoptosis. Toxicol Appl Pharmacol. 2004 Aug 1;198(3):354-65.


Taken together, these data indicate that cellular GSH was required for DMAs (V)-induced apoptosis to occur, and activation of cellular caspases after conjugation of DMAs (V) with cellular GSH appears to be of mechanistic significance.
1(0,0,0,1) Details