Protein Information

Name Ha ras
Synonyms C H RAS; Transforming protein p21; N ras; HRAS1; HRASP; C H ras 1 protein N terminal fragment (37 AA); C has/bas p21 protein; C ras Ki 2 protein…

Compound Information

Name cacodylic acid
CAS dimethylarsinic acid

Reference List

PubMed Abstract RScore(About this table)
15345372 Xie Y, Trouba KJ, Liu J, Waalkes MP, Germolec DR: Biokinetics and subchronic toxic effects of oral arsenite, arsenate, monomethylarsonic acid, and dimethylarsinic acid in v-Ha-ras transgenic (Tg.AC) mice. Environ Health Perspect. 2004 Aug;112(12):1255-63.

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12151359 Wei M, Wanibuchi H, Morimura K, Iwai S, Yoshida K, Endo G, Nakae D, Fukushima S: Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis. 2002 Aug;23(8):1387-97.


Mutation analysis showed that DMA-induced rat urinary bladder tumors had a low rate of H-ras mutations (2 of 20, 10%).
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19386250 Muramatsu D, Sasaki K, Kuroda S, Hayashi K, Tanaka N, Sakai A: Comparison of sensitivity to arsenic compounds between a Bhas 42 cell transformation assay and a BALB/c 3T3 cell transformation assay. Mutat Res. 2009 Apr 30;675(1-2):66-70. Epub 2009 Feb 28.


A short-term cell transformation assay has recently been developed, using Bhas 42 cells which were established from BALB/c 3T3 cells transfected by v-Ha-ras gene and postulated to be initiated in the two-stage carcinogenesis theory.
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