Protein Information

Name interferon gamma
Synonyms IFG; IFI; IFN gamma; IFNG; IFNgamma; Immune interferon; Interferon gamma; Interferon gamma precursor…

Compound Information

Name propanil
CAS

Reference List

PubMed Abstract RScore(About this table)
7679225 Theus SA, Tabor DR, Gandy J, Barnett JB: Alteration of macrophage cytotoxicity through endogenous interferon and tumor necrosis factor alpha induction by propanil. Toxicol Appl Pharmacol. 1993 Jan;118(1):46-52.

Although control animals showed a typical pattern of requiring both interferon (IFN)-gamma and lipopolysaccharide (LPS) for m phi activation, m phi from propanil-treated animals were cytotoxic when induced with LPS alone.
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9761131 Zhao W, Schafer R, Barnett JB: Cytokine production by C57BL/6 mouse spleen cells is selectively reduced by exposure to propanil. J Toxicol Environ Health A. 1998 Sep 25;55(2):107-20.

In vivo exposure to propanil caused the reduction of interleukin (IL)-2, IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interferon (IFN)-gamma production in concanavalin A-stimulated spleen cell cultures established 2 d after exposure.
81(1,1,1,1) Details
10933756 Watson VA, Barnett JB, Schafer R: In vivo cytokine production and resistance to infection after acute exposure to 3,4-dichloropropionaniline. J Toxicol Environ Health A. 2000 Jul 28;60(6):391-406.

Our experiments demonstrate that in vivo exposure to propanil during bacterial infection reduced the subsequent in vitro production of interferon-gamma (IFN-gamma) by splenocytes and liver nonparenchymal cells in response to antigenic and mitogenic stimulation.
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