| Name | cholinesterase |
|---|---|
| Synonyms | Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase… |
| Name | propoxur |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 893210 | Fisch H, Angerhofer RA, Nelson JH: Evaluation of a -impregnated flea and tick collar for dogs. J Am Vet Med Assoc. 1977 Aug 1;171(3):269-70. To acquire information regarding the potential hazard of pesticide-impregnated collars to dogs, 13 male Beagles were allotted to 2 groups; 8 of the dogs were fitted wtih propoxur-impregnated tick and flea collars and the other 5 were fitted with placebo collars. The dogs wearing test collars had significant (P less than 0.01) depression of erythrocyte and plasma cholinesterase activities at day 1 after collar application; however, the enzyme activity values returned to the preexposure range within 3 days. |
1(0,0,0,1) | Details |
| 17188317 | Kobayashi H, Suzuki T, Sakamoto M, Hashimoto W, Kashiwada K, Sato I, Akahori F, Satoh T: Brain regional acetylcholinesterase activity and muscarinic acetylcholine receptors in rats after repeated administration of cholinesterase inhibitors and its withdrawal. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):151-61. Epub 2006 Nov 11. Activity of acetylcholinesterase (AChE) and specific binding of [(3) H] quinuclidinyl benzilate (QNB), [(3) H] pirenzepine (PZP) and [(3) H] AF-DX 384 to muscarinic acetylcholine receptor (mAChR) preparations in the striatum, hippocampus and cortex of rats were determined 1, 6 and 11 days after the last treatment with an organophosphate DDVP, a propoxur or a muscarinic agonist oxotremorine as a reference for 7 and 14 days. |
1(0,0,0,1) | Details |
| 15180375 | Printes LB, Callaghan A: A comparative study on the relationship between acetylcholinesterase activity and acute toxicity in Daphnia magna exposed to anticholinesterase insecticides. Environ Toxicol Chem. 2004 May;23(5):1241-7. Acetylcholinesterase (AChE) activity was measured in Daphnia magna that had been exposed to four organophosphates (OPs; parathion, chlorpyrifos, malathion, and acephate) and one (propoxur) for 48 h. |
1(0,0,0,1) | Details |
| 19371420 | Bonnet J, Pennetier C, Duchon S, Lapied B, Corbel V: Multi-function oxidases are responsible for the synergistic interactions occurring between repellents and insecticides in mosquitoes. Parasit Vectors. 2009 Apr 16;2(1):17. METHODS: Topical applications of DEET and propoxur used alone or as a mixture, were carried out on female mosquitoes, using inhibitors of the two main detoxification pathways in the insect. This suggests that oxidases, contrary to esterases, play a key role in the interactions occurring between DEET and cholinesterase inhibitors in mosquitoes. |
1(0,0,0,1) | Details |
| 9057895 | Futagawa H, Kakinuma Y, Takahashi H: Cardiovascular collapse through non-cholinergic mechanism after intravenous injection of N-methylcarbamate insecticide in rabbits. Toxicology. 1997 Feb 28;117(2-3):163-70. This study was undertaken to investigate whether cholinesterase (ChE) inhibitor exerts cardiovascular collapse through non-cholinergic mechanism in halothane-anesthetized rabbits. Physostigmine and N-methylcarbamate insecticides (BPMC = 2-sec-butylphenyl methylcarbamate and PHC = propoxur = 2-isopropoxyphenyl methylcarbamate) were employed as ChE inhibitors. |
1(0,0,0,1) | Details |
| 1035672 | Kimmerle G, Iyatomi A: Toxicity of propoxur to rats by subacute inhalation. Sangyo Igaku. 1976 Jul;18(4):375-82. The effects were depressions of plasma by 20 to 30%, and of erythrocyte and brain cholinesterase activities which were caused by the highest air concentration of 31.7 mg/m3. |
1(0,0,0,1) | Details |
| 7974514 | Takahashi H, Kakinuma Y, Futagawa H: Non-cholinergic lethality following intravenous injection of insecticide in rabbits. Toxicology. 1994 Nov 11;93(2-3):195-207. This study was undertaken to investigate the possibility that non-cholinergic mechanism accounts for acute lethality of cholinesterase (ChE) inhibitor. Physostigmine and insecticides (2-s-butylphenyl methylcarbamate (BPMC); isoprocarb, 2-isopropylphenyl methylcarbamate (MIPC); and propoxur, 2-isopropoxyphenyl methylcarbamate (PHC)) were employed as ChE inhibitors. |
1(0,0,0,1) | Details |
| 7464034 | Lavender RG, Stark DM: Efficacy of propoxur insecticide strip use in a laboratory animal facility. Lab Anim Sci. 1980 Dec;30(6):984-7. |
0(0,0,0,0) | Details |
| 17950890 | Mwanza JC, Finley D, Spivey CL, Graff JE, Herr DW: Depression of the photic after discharge of flash evoked potentials by physostigmine, carbaryl and propoxur, and the relationship to inhibition of brain cholinesterase. Neurotoxicology. 2008 Jan;29(1):87-100. Epub 2007 Sep 14. |
82(1,1,1,2) | Details |
| 17197007 | Padilla S, Marshall RS, Hunter DL, Lowit A: Time course of cholinesterase inhibition in adult rats treated acutely with carbaryl, carbofuran, formetanate, methomyl, methiocarb, oxamyl or propoxur. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):202-9. Epub 2006 Nov 15. |
82(1,1,1,2) | Details |
| 9862655 | Shukla Y, Baqar SM, Mehrotra NK: Carcinogenicity and co-carcinogenicity studies on propoxur in mouse skin. . Food Chem Toxicol. 1998 Dec;36(12):1125-30. Propoxur exposure is reported to inhibit cholinesterase activity in rodents. |
81(1,1,1,1) | Details |
| 10082314 | Thiesen FV, Barros HM, Tannhauser M, Tannhauser SL: Behavioral changes and cholinesterase activity of rats acutely treated with propoxur. Jpn J Pharmacol. 1999 Jan;79(1):25-31. Maximum inhibition of blood cholinesterase was observed within 30 min after administration of propoxur. |
81(0,2,5,6) | Details |
| 6408651 | Ruppert PH, Cook LL, Dean KF, Reiter LW: Acute behavioral toxicity of carbaryl and propoxur in adult rats. Pharmacol Biochem Behav. 1983 Apr;18(4):579-84. Motor activity and neuromotor function were examined in adult CD rats exposed to either carbaryl or propoxur, and behavioral effects were compared with the time course of cholinesterase inhibition. |
45(0,1,3,5) | Details |
| 3591016 | Pfordt J, Magerl H, Vock R: [Fatal poisonings with propoxur] . Z Rechtsmed. 1987;98(1):43-8. The insecticide propoxur (2-isopropoxyphenyl-N-methylcarbamate) acts by blocking cholinesterase. |
81(1,1,1,1) | Details |
| 1238091 | Iverson F: Affinity and carbamylation rate constants of propoxur in reaction with erythrocyte and serum cholinesterase. Biochem Pharmacol. 1975 Aug 15;24(16):1537-8. |
31(0,1,1,1) | Details |
| 2035247 | Iyaniwura TT: Relative inhibition of rat plasma and erythrocyte cholinesterases by pesticide combinations. Vet Hum Toxicol. 1991 Apr;33(2):166-8. A selected combination of pesticides (carbofuran, oxamyl and propoxur were examined for cholinesterase (ChE) inhibition. |
32(0,1,1,2) | Details |
| 7090014 | Srivastava AK, Singh NN: Acute toxicity of propoxur on carbohydrate metabolism of Indian catfish (Heteropneustes fossilis). Toxicol Lett. 1982 Apr;11(1-2):31-4. The observed effects are explained in terms of acute stress syndrome; possible mechanisms underlying the effect of anticholinesterase action of propoxur on carbohydrate metabolism are also discussed. |
31(0,1,1,1) | Details |
| 3416473 | Remaley AT, Hicks DG, Kane MD, Shaw LM: Laboratory assessment of poisoning with a insecticide. Clin Chem. 1988 Sep;34(9):1933-6. Capillary gas chromatography and electron-impact mass fragmentographic analysis of the patient's urine and serum demonstrated the presence of poly-ethylene glycol and propoxur (o-isopropoxyphenyl N-methyl- a -based cholinesterase inhibitor commonly used in insecticides. |
31(0,1,1,1) | Details |
| 11993279 | Pogacnik L, Franko M: Validation of different commercially available cholinesterases for pesticide toxicity test. Ann Chim. 2002 Jan-Feb;92(1-2):93-101. A systematic study of different commercially available cholinesterases (AChEs from electric eel, human erythrocytes, bovine erythrocytes and BuChE from horse serum) for the FIA determination of some frequently used organophosphate (paraoxon, oxydemeton-methyl, triazophos, diazionon) and (carbofuran, propoxur) pesticides was carried out. |
10(0,0,1,5) | Details |
| 18968286 | Pogacnik L, Franko M: Optimisation of FIA system for detection of organophosphorus and pesticides based on cholinesterase inhibition. Talanta. 2001 May 30;54(4):631-41. Responses to some frequently used organophosphorus (paraoxon, oxydemeton-methyl, triazophos) and (carbofuran, propoxur) pesticides were found to be dependent on the origin of cholinesterases. |
9(0,0,1,4) | Details |
| 6855183 | Weisbroth SP, Weisbroth SH, Grey RM: Effect of propoxur-impregnated pesticide tape on mouse cholinesterase levels. Lab Anim Sci. 1983 Apr;33(2):151-3. |
8(0,0,1,3) | Details |
| 6642106 | Costa LG, Murphy SD: Unidirectional cross-tolerance between the insecticide propoxur and the organophosphate disulfoton in mice. Fundam Appl Toxicol. 1983 Sep-Oct;3(5):483-8. Mice tolerant to propoxur were cross-tolerant to the hypothermic and anticholinesterase effects of disulfoton. |
7(0,0,1,2) | Details |
| 10472315 | Leng G, Lewalter J: Role of individual susceptibility in risk assessment of pesticides. Occup Environ Med. 1999 Jul;56(7):449-53. For exposure to propoxur the propoxur concentration in plasma, the 2-isopropoxyphenol concentration in urine, and the cholinesterase and acetylcholinesterase activities were measured. |
7(0,0,1,2) | Details |
| 3411818 | Kobayashi H, Yuyama A, Ohkawa T, Kajita T: Effect of single or chronic injection with a propoxur, on the brain cholinergic system and behavior of mice. Jpn J Pharmacol. 1988 May;47(1):21-7. Propoxur, an anticholinesterase was injected singly (10 mg/kg, s.c.) or chronically (5 mg/kg/day, s.c., for 10 days) into mice. |
6(0,0,1,1) | Details |
| 8083479 | Kobayashi H, Sato I, Akatsu Y, Fujii S, Suzuki T, Matsusaka N, Yuyama A: Effects of single or repeated administration of a propoxur, and an organophosphate, DDVP, on jejunal cholinergic activities and contractile responses in rats. J Appl Toxicol. 1994 May-Jun;14(3):185-90. In summary, propoxur and DDVP showed similar effects mainly through their anticholinesterase properties in the case of single injection, but DDVP had similar effects to those of oxotremorine and propoxur had similar effects to those of atropine in the case of repeated injection. |
6(0,0,1,1) | Details |
| 7150808 | Krechniak J, Foss W: Cholinesterase activity in rats treated with propoxur. Bull Environ Contam Toxicol. 1982 Nov;29(5):599-604. |
6(0,0,1,1) | Details |
| 3672530 | Pauluhn J, Machemer L, Kimmerle G: Effects of inhaled cholinesterase inhibitors on bronchial tonus and on plasma and erythrocyte acetylcholine esterase activity in rats. Toxicology. 1987 Oct 30;46(2):177-90. The compounds tested were dichlorvos, fenamiphos, methamidophos, parathion, a pyrimidine thiophosphate and the propoxur. |
6(0,0,0,6) | Details |
| 2256706 | Gupta RC, Kadel WL: Toxic interaction of tetraisopropylpyrophosphoramide and propoxur: some insights into the mechanisms. Arch Environ Contam Toxicol. 1990 Nov-Dec;19(6):917-20. Propoxur with a non-toxic dose (5 mg/kg) administered intraperitoneally (ip) in tetraisopropylpyrophosphoramide (iso-OMPA, 1 mg/kg) pretreated rats subcutaneously, sc) produced severe intoxication of anticholinesterase nature. |
6(0,0,1,1) | Details |
| 17504769 | McDaniel KL, Padilla S, Marshall RS, Phillips PM, Podhorniak L, Qian Y, Moser VC: Comparison of acute neurobehavioral and cholinesterase inhibitory effects of N-methylcarbamates in rat. Toxicol Sci. 2007 Aug;98(2):552-60. Epub 2007 May 15. The chemicals tested were carbaryl, carbofuran, formetanate, methiocarb, methomyl, oxamyl, and propoxur. |
3(0,0,0,3) | Details |
| 10814550 | Futagawa H, Kakinuma Y, Takahashi H: The role of cholinergic and noncholinergic mechanisms in the cardiorespiratory failure produced by N-methylcarbamate cholinesterase inhibitors in rabbits. Toxicol Appl Pharmacol. 2000 May 15;165(1):27-36. |
2(0,0,0,2) | Details |
| 3371194 | Moody SB, Terp DK: Dystonic reaction possibly induced by cholinesterase inhibitor insecticides. Drug Intell Clin Pharm. 1988 Apr;22(4):311-2. |
2(0,0,0,2) | Details |
| 8431675 | Kumar R, Madhavi NB, Sharma CB: Biodegradation of a pesticide, Propoxur, in rat tissues. Biomed Chromatogr. 1993 Jan-Feb;7(1):20-4. The pesticide also induced haematological changes such as an increased level of total bilubrin, amylase and glutamic-oxalacetic transaminase and decrease of cholinesterase activity, indicating damage of the liver and nervous system in rats. |
1(0,0,0,1) | Details |
| 19656357 | Corbel V, Stankiewicz M, Pennetier C, Fournier D, Stojan J, Girard E, Dimitrov M, Molgo J, Hougard JM, Lapied B: Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet. BMC Biol. 2009 Aug 5;7:47. |
1(0,0,0,1) | Details |