Protein Information

Name PTP1B
Synonyms PTP 1B; PTP1B; PTPN 1; PTPN1; Protein tyrosine phosphatase 1B; Tyrosine protein phosphatase non receptor type 1; Protein tyrosine phosphatase 1Bs; Tyrosine protein phosphatase non receptor type 1s

Compound Information

Name nitrostyrene
CAS 4-(2-nitro-1-propenyl)phenyl thiocyanate

Reference List

PubMed Abstract RScore(About this table)
15554709 Park J, Pei D: trans-Beta-nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases. Biochemistry. 2004 Nov 30;43(47):15014-21.

In this work, trans-beta-nitrostyrene (TBNS) and its derivatives are found to be slow-binding inhibitors against protein tyrosine phosphatases PTP1B, SHP-1, and Yop with moderate potencies (K (I*) = 1-10 microM).
82(1,1,1,2) Details