| Name | caspase 3 |
|---|---|
| Synonyms | Apopain; CASP 3; CASP3; CPP 32; CPP32; CPP32B; Caspase 3; Caspase 3 precursor… |
| Name | nitrostyrene |
|---|---|
| CAS | 4-(2-nitro-1-propenyl)phenyl thiocyanate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18086538 | Werner JM, Steinfelder HJ: A microscopic technique to study kinetics and concentration-response of drug-induced caspase-3 activation on a single cell level. J Pharmacol Toxicol Methods. 2008 Mar-Apr;57(2):131-7. Epub 2007 Nov 12. To study kinetics and concentration-response of drug-induced caspase-3 activation we exposed cells towards trans-beta-nitrostyrene, a rapidly acting experimental agent, as well as towards 5-fluorouracil, a standard agent with slow pro-apoptotic kinetics. |
86(1,1,1,6) | Details |
| 17136318 | Werner JM, Eger K, Jurgen Steinfelder H: Comparison of the rapid pro-apoptotic effect of trans-beta-nitrostyrenes with delayed apoptosis induced by the standard agent 5-fluorouracil in colon cancer cells. Apoptosis. 2007 Jan;12(1):235-46. Trans-beta-nitrostyrene (TBNS) has been reported to be a potent inhibitor of protein phosphatases PTB1 and PP2A and to display a pro-apoptotic effect even in multidrug resistant tumour cells. DNA fragmentation and caspase-3 assays confirmed the more rapid apoptotic effect of TBNS. |
2(0,0,0,2) | Details |