Protein Information

Name platelet glycoprotein IIb
Synonyms Alpha 2B integrin; CD41; CD41 antigen; CD41B; GP2B; GPIIb; GPalpha IIb; GTA…

Compound Information

Name nitrostyrene
CAS 4-(2-nitro-1-propenyl)phenyl thiocyanate

Reference List

PubMed Abstract RScore(About this table)
16837624 Wang WY, Wu YC, Wu CC: Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosine kinase inhibitor. Mol Pharmacol. 2006 Oct;70(4):1380-9. Epub 2006 Jul 12.
84(1,1,1,4) Details
17601492 Wang WY, Hsieh PW, Wu YC, Wu CC: Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem Pharmacol. 2007 Aug 15;74(4):601-11. Epub 2007 Jun 3.

The beta-nitrostyrene derivatives inhibited thrombin- or collagen-induced human platelet aggregation, ATP secretion, GPIIb/IIIa activation and protein tyrosine phosphorylation.
31(0,1,1,1) Details