| Name | PP2A |
|---|---|
| Synonyms | PP2A; PP2A subunit B prime; PR53; PTPA; Phosphotyrosyl phosphatase activator; Serine/threonine protein phosphatase 2A regulatory subunit B'; PP2A subunit B primes… |
| Name | nitrostyrene |
|---|---|
| CAS | 4-(2-nitro-1-propenyl)phenyl thiocyanate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10915062 | Fathi AR, Krautheim A, Kaap S, Eger K, Steinfelder HJ: Michael adducts of as inhibitors of protein phosphatase 2A and inducers of apoptosis. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1605-8. A nitrostyrene adduct of proved to be a more potent and effective inhibitor of PP2A as well as a stronger inducer of apoptosis. |
82(1,1,1,2) | Details |
| 17136318 | Werner JM, Eger K, Jurgen Steinfelder H: Comparison of the rapid pro-apoptotic effect of trans-beta-nitrostyrenes with delayed apoptosis induced by the standard agent 5-fluorouracil in colon cancer cells. Apoptosis. 2007 Jan;12(1):235-46. Trans-beta-nitrostyrene (TBNS) has been reported to be a potent inhibitor of protein phosphatases PTB1 and PP2A and to display a pro-apoptotic effect even in multidrug resistant tumour cells. |
81(1,1,1,1) | Details |