Protein Information

Name S rRNA
Synonyms 12S RNA; MT RNR1; MTRNR 1; MTRNR1; RNR 1; RNR1; mitochondrially encoded 12S RNA; s rRNA…

Compound Information

Name kasugamycin
CAS

Reference List

PubMed Abstract RScore(About this table)
11327780 Vila-Sanjurjo A, Dahlberg AE: Mutational analysis of the conserved bases C1402 and A1500 in the center of the decoding domain of Escherichia coli 16 S rRNA reveals an important tertiary interaction. J Mol Biol. 2001 May 4;308(3):457-63.

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8064863 Lafontaine D, Delcour J, Glasser AL, Desgres J, Vandenhaute J: The DIM1 gene responsible for the conserved m6 (2) Am6 (2) A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast. J Mol Biol. 1994 Aug 19;241(3):492-7.

Disruption of ksgA confers resistance to the aminoglycoside antibiotic kasugamycin without significantly impairing viability.
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6163627 Igarashi K, Kishida K, Kashiwagi K, Tatokoro I, Kakegawa T, Hirose S: Relationship between methylation of adenine near the 3' end of 16-S ribosomal RNA and the activity of 30-S ribosomal subunits. Eur J Biochem. 1981 Jan;113(3):587-93.

The relationship between methylation of adenine near the 3' end of 16-S ribosomal RNA and the activity of 30-S ribosomal subunits has been studied using 30-S subunits from kasugamycin-sensitive and kasugamycin-resistant bacteria.
These results suggest that methylation of adenine near the 3' end of 16-S rRNA induces an increase of polypeptide-synthetic activity by the acceleration of binding of protein S1 to S1-depleted 30-S subunits.
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