| 6488393 |
Thompson JA, Ho B, Mastovich SL: Reductive metabolism of 1,1,1,2-tetrachloroethane and related chloroethanes by rat liver microsomes. Chem Biol Interact. 1984 Oct;51(3):321-33.
Metabolites produced from 1,1,1,2-tetrachloroethane in vitro were 1,1-dichloroethylene (DCE) and 1,1,2-trichloroethane (TCEA) and the ratio DCE/TCEA was about 25:1. |
37(0,1,2,2) |
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| 3426575 |
Hales DB, Ho B, Thompson JA: Inter- and intramolecular deuterium isotope effects on the cytochrome P-450-catalyzed oxidative dehalogenation of 1,1,2,2-tetrachloroethane. Biochem Biophys Res Commun. 1987 Dec 16;149(2):319-25.
These data, and the finding that 1 atom of 18O was incorporated into the product when TCEA was oxidized in an 18O2 atmosphere, support an oxidative dechlorination mechanism that involves hydrogen atom abstraction by the P-450 intermediate oxo complex. |
1(0,0,0,1) |
Details |