Protein Information

Name SLY1
Synonyms FKSG23; RA410; SCFD 1; SCFD1; SLY 1; SLY1; STXBP1L2; Sec1 family domain containing 1…

Compound Information

Name gibberellins
CAS gibberellins

Reference List

PubMed Abstract RScore(About this table)
15308775 Strader LC, Ritchie S, Soule JD, McGinnis KM, Steber CM: Recessive-interfering mutations in the gibberellin signaling gene SLEEPY1 are rescued by overexpression of its homologue, SNEEZY. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12771-6. Epub 2004 Aug 12.


This article reports the genetic interaction of two F-box genes, SLEEPY1 (SLY1) and SNEEZY (SNE), in Arabidopsis thaliana gibberellin (GA) signaling.
7(0,0,0,7) Details
12724538 McGinnis KM, Thomas SG, Soule JD, Strader LC, Zale JM, Sun TP, Steber CM: The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase. Plant Cell. 2003 May;15(5):1120-30.


The Arabidopsis SLY1 (SLEEPY1) gene positively regulates gibberellin (GA) signaling.
6(0,0,0,6) Details
15161962 Fu X, Richards DE, Fleck B, Xie D, Burton N, Harberd NP: The Arabidopsis mutant sleepy1gar2-1 protein promotes plant growth by increasing the affinity of the SCFSLY1 E3 ubiquitin ligase for DELLA protein substrates. Plant Cell. 2004 Jun;16(6):1406-18. Epub 2004 May 25.


Here, we show that the Arabidopsis thaliana sleepy1gar2-1 (sly1gar2-1) mutant allele encodes a mutant subunit (sly1gar2-1) of an SCF (SLY1) E3 ubiquitin ligase complex.
4(0,0,0,4) Details
15155881 Dill A, Thomas SG, Hu J, Steber CM, Sun TP: The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation. Plant Cell. 2004 Jun;16(6):1392-405. Epub 2004 May 21.


SLEEPY1 (SLY1) encodes an F-box-containing protein, and the loss-of-function sly1 mutant has a GA-insensitive dwarf phenotype and accumulates a high level of RGA.
4(0,0,0,4) Details
17384169 Ariizumi T, Steber CM: Seed germination of GA-insensitive sleepy1 mutants does not require RGL2 protein disappearance in Arabidopsis. Plant Cell. 2007 Mar;19(3):791-804. Epub 2007 Mar 23.


We explore the roles of gibberellin (GA) signaling genes SLEEPY1 (SLY1) and RGA-LIKE2 (RGL2) in regulation of seed germination in Arabidopsis thaliana, a plant in which the hormone GA is required for seed germination.
2(0,0,0,2) Details
18827182 Ariizumi T, Murase K, Sun TP, Steber CM: Proteolysis-independent downregulation of DELLA repression in Arabidopsis by the gibberellin receptor GIBBERELLIN INSENSITIVE DWARF1. Plant Cell. 2008 Sep;20(9):2447-59. Epub 2008 Sep 30.


DELLA degradation requires GA biosynthesis, three functionally redundant GA receptors GIBBERELLIN INSENSITIVE DWARF1 (GID1a, b, and c), and the SLEEPY1 (SLY1) F-box subunit of an SCF E3 ubiquitin ligase.
2(0,0,0,2) Details
15173565 Tyler L, Thomas SG, Hu J, Dill A, Alonso JM, Ecker JR, Sun TP: Della proteins and gibberellin-regulated seed germination and floral development in Arabidopsis. Plant Physiol. 2004 Jun;135(2):1008-19. Epub 2004 Jun 1.


We showed that RGL2 protein in imbibed seeds is rapidly degraded by GA treatment and that the F-box protein SLY1 is required for RGL2 degradation to occur.
1(0,0,0,1) Details
18077204 Schwechheimer C: Understanding gibberellic acid signaling--are we there yet? . Curr Opin Plant Biol. 2008 Feb;11(1):9-15.


The current view is that GA binds to a soluble GID1 receptor, which interacts with the DELLA repressor proteins in a GA-dependent manner and thereby induces DELLA protein degradation via the E3 ubiquitin ligase SCF (GID2/SLY1).
1(0,0,0,1) Details
9611170 Steber CM, Cooney SE, McCourt P: Isolation of the GA-response mutant sly1 as a suppressor of ABI1-1 in Arabidopsis thaliana. Genetics. 1998 Jun;149(2):509-21.


Thus, we postulate that SLY1 is a key factor in GA reception.
1(0,0,0,1) Details
17194763 Griffiths J, Murase K, Rieu I, Zentella R, Zhang ZL, Powers SJ, Gong F, Phillips AL, Hedden P, Sun TP, Thomas SG: Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis. Plant Cell. 2006 Dec;18(12):3399-414. Epub 2006 Dec 28.


Furthermore, yeast three-hybrid assays showed that the GA-GID1 complex promotes the interaction between RGA and the F-box protein SLY1, a component of the SCF (SLY1) E3 ubiquitin ligase that targets the DELLA protein for degradation.
1(0,0,0,1) Details