Protein Information

Name olfactory receptors (protein family or complex)
Synonyms Olfactory Receptor; Olfactory Receptors

Compound Information

Name carvone
CAS 2-methyl-5-(1-methylethenyl)-2-cyclohexen-1-one

Reference List

PubMed Abstract RScore(About this table)
8024034 Hanada T, Kashiwayanagi M, Kurihara K: Temperature increase abolishes ability of turtle olfactory receptors to discriminate similar odorant. Am J Physiol. 1994 Jun;266(6 Pt 2):R1816-23.

The ability of the olfactory receptors to discriminate pairs of odorants having similar structures (e.g., trans-3-hexenol and cis-3-hexenol; d-carvone and l-carvone) was reversibly abolished by increasing the temperature up to 40 degrees C, whereas discrimination of odorants having quite different structures was much less affected.
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9875846 Krautwurst D, Yau KW, Reed RR: Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell. 1998 Dec 23;95(7):917-26.

Three receptors were identified to respond to micromolecular concentrations of carvone, (-) citronellal, and limonene, respectively.
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2914071 Polak EH, Fombon AM, Tilquin C, Punter PH: Sensory evidence for olfactory receptors with opposite chiral selectivity. Behav Brain Res. 1989 Jan 1;31(3):199-206.

These same nine subjects, when tested for threshold sensitivity to carvone enantiomers, showed (+)/(-) ratios that varied only in a narrow range and did not correlate with their ionone ratios.
1(0,0,0,1) Details
8207942 Hahn I, Scherer PW, Mozell MM: A mass transport model of olfaction. J Theor Biol. 1994 Mar 21;167(2):115-28.

A theoretical model of olfaction involving all the major mechanisms in the mass transport of odorant molecules from inspired air to the olfactory receptors is developed.
The model predicts that, given adequate mucus surface for sorption, increase in the flow rate results in an increase in perceived odor intensity for the readily sorbed or highly soluble odorants (such as carvone) and a decrease in odor intensity for the poorly sorbed or insoluble odorants (such as octane).
1(0,0,0,1) Details
11439452 Laska M, Galizia CG: Enantioselectivity of odor perception in honeybees (Apis mellifera carnica). Behav Neurosci. 2001 Jun;115(3):632-9.

The bees (a) significantly distinguished between 98% of the 540 odor pairs tested, thus showing an excellent overall discrimination performance, and (b) were able to discriminate between the optical isomers of limonene, alpha-pinene, beta-citronellol, menthol, and carvone but failed to distinguish between the (+)- and (-)-forms of alpha-terpineol, camphor, rose oxide, fenchone, and 2-butanol.
The findings support the assumptions that enantioselective molecular odor receptors may exist only for some volatile enantiomers and that insects and mammals may share common principles of odor quality perception, irrespective of their completely differing repertoires of olfactory receptors.
1(0,0,0,1) Details