| Name | fibronectin |
|---|---|
| Synonyms | CIG; MSF; Cold insoluble globulin; FINC; FN; FN1; Fibronectin; Fibronectin 1… |
| Name | sodium chlorate |
|---|---|
| CAS | sodium chlorate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8844403 | Melo F, Carey DJ, Brandan E: Extracellular matrix is required for skeletal muscle differentiation but not myogenin expression. J Cell Biochem. 1996 Aug;62(2):227-39. treatment was also found to inhibit the deposition and assembly of ECM components such fibronectin and laminin. |
1(0,0,0,1) | Details |
| 18515587 | Keller KE, Bradley JM, Kelley MJ, Acott TS: Effects of modifiers of glycosaminoglycan biosynthesis on outflow facility in perfusion culture. Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2495-505. Fibronectin immunostaining was altered in beta-xyloside-treated eyes, whereas in cell culture, induced formation of thick fibronectin fibrils, to which tenascin C colocalized. METHODS: Outflow facility was measured in perfused porcine and human anterior organ cultures treated with 20 or 50 mM sodium chlorate, or 1 mM beta-xyloside. |
1(0,0,0,1) | Details |
| 12694655 | Kokenyesi R, Murray KP, Benshushan A, Huntley ED, Kao MS: Invasion of interstitial matrix by a novel cell line from primary peritoneal carcinosarcoma, and by established ovarian carcinoma cell lines: role of cell-matrix adhesion molecules, proteinases, and E-cadherin expression. Gynecol Oncol. 2003 Apr;89(1):60-72. RESULTS: PC880 cells adhered well to fibronectin, laminin, and vitronectin in an integrin-dependent manner. Treatment of PC880 cells with sodium chlorate also decreased invasiveness (80% of control), further confirming the role of cell surface proteoglycans. |
1(0,0,0,1) | Details |
| 14585398 | Gao R, Brigstock DR: Low density lipoprotein receptor-related protein (LRP) is a -dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatol Res. 2003 Nov;27(3):214-220. Co-incubation of CTGF with or perturbation of cell surface HSPGs with heparinase or sodium chlorate completely blocked adhesion of activated HSCs to all CTGF isoforms. Freshly isolated HSCs demonstrated only weak binding to CTGF but strong binding to fibronectin. |
1(0,0,0,1) | Details |
| 8373355 | Liu J, Han JR, Liu CC, Suiko M, Liu MC: Identification of a putative -O-sulphate (TyrS) receptor possibly functioning in the biosynthetic transport of -sulphated proteins in Madin-Darby canine kidney cells. Biochem J. 1993 Sep 1;294 ( Pt 2):407-17. When the cell lysate used was prepared from MDCK cells pretreated with 20 mM sodium chlorate, a metabolic sulphation inhibitor, the complex formed between the two proteins could no longer be detected, indicating that the binding of the TyrS-binding protein is through the TyrS residue (s) of gp 80. Furthermore, radioactive pulse-chase experiments revealed that the newly synthesized radiolabelled fibronectin and gp 80 were present in complexes with the TyrS-binding protein in MDCK cells pulse-labelled with [35S] or [35S] sulphate. |
1(0,0,0,1) | Details |
| 8725286 | Choy M, Oltjen SL, Otani YS, Armstrong MT, Armstrong PB: Fibroblast growth factor-2 stimulates embryonic cardiac mesenchymal cell proliferation. Dev Dyn. 1996 Jun;206(2):193-200. Inhibition of sulfation of cell surface glycosaminoglycans by treatment with sodium chlorate significantly reduced both the formation of the fibronectin matrix and cell proliferation in response to FGF-2, suggesting an involvement of the low-affinity sulfated glycosaminoglycan FGF receptor system. |
85(1,1,1,5) | Details |
| 9344714 | Chon JH, Wang HS, Chaikof EL: Role of fibronectin and sulfated proteoglycans in endothelial cell migration on a cultured smooth muscle layer. J Surg Res. 1997 Sep;72(1):53-9. The EC carrying beads were spread over a confluent human aortic SMC monolayer and cocultured for 48 hr, allowing the EC to migrate from beads onto the underlying SMC monolayer in the presence of sodium chlorate, cycloheximide (CHM), or anti-fibronectin monoclonal antibody (anti-FN mAb). |
8(0,0,1,3) | Details |
| 12485624 | Mendes de Aguiar CB, Garcez RC, Alvarez-Silva M, Trentin AG: Undersulfation of proteoglycans and proteins alter C6 glioma cells proliferation, adhesion and extracellular matrix organization. Int J Dev Neurosci. 2002 Nov;20(7):563-71. In this work we verified that undersulfation of proteoglycans and other sulfated molecules, induced by sodium chlorate treatment, inhibited C6 glioma cells proliferation in a dose-dependent way. The treatment also impaired in a dose-dependent manner, C6 cell adhesion to extracellular matrix (ECM) proteins (collagen IV, laminin and fibronectin). |
2(0,0,0,2) | Details |
| 11788350 | Osses N, Brandan E: ECM is required for skeletal muscle differentiation independently of muscle regulatory factor expression. Am J Physiol Cell Physiol. 2002 Feb;282(2):C383-94. To assess the role of the extracellular matrix (ECM) in skeletal muscle differentiation, the specific inhibitors of proteoglycan synthesis, sodium chlorate and beta-D-xyloside, were used. Myoblast treatment with each inhibitor affected the deposition and assembly of the ECM constituents glypican, fibronectin, and laminin. |
1(0,0,0,1) | Details |
| 15381066 | Cho YR, Lee SJ, Jeon HB, Park ZY, Chun JS, Yoo YJ: Under-sulfation by synthetase inhibition modulates the expression of ECM molecules during chondrogenesis. Biochem Biophys Res Commun. 2004 Oct 22;323(3):769-75. We found that sodium chlorate, a specific inhibitor of synthetase, inhibited proteoglycan sulfation during chondrogenesis. Inhibition of sulfation also accelerated the down-regulation of N-cadherin and fibronectin during chondrogenesis. |
1(0,0,0,1) | Details |