| Name | Heparan sulfate proteoglycan |
|---|---|
| Synonyms | CD44; LHR; Heparan sulfate proteoglycan; CD44 antigen; CD44 antigen (Indian blood group); CD44 antigen (homing function and Indian blood group system); CD44 antigen precursor; CD44 molecule (Indian blood group)… |
| Name | sodium chlorate |
|---|---|
| CAS | sodium chlorate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15767480 | Siffroi-Fernandez S, Cinaroglu A, Fuhrmann-Panfalone V, Normand G, Bugra K, Sahel J, Hicks D: Acidic fibroblast growth factor (FGF-1) and FGF receptor 1 signaling in human Y79 retinoblastoma. Arch Ophthalmol. 2005 Mar;123(3):368-76. Low-affinity heparan sulfate proteoglycan coreceptors were blocked through sodium chlorate or heparinase treatment of Y79 cells. |
82(1,1,1,2) | Details |
| 11821431 | Kawashima H, Atarashi K, Hirose M, Hirose J, Yamada S, Sugahara K, Miyasaka M: Oversulfated / sulfates containing GlcAbeta1/IdoAalpha1-3GalNAc (4,6-O-disulfate) interact with L- and P-selectin and chemokines. J Biol Chem. 2002 Apr 12;277(15):12921-30. Epub 2002 Jan 30. Using a metabolic inhibitor of sulfation, sodium chlorate, we show that the interactions of the CS/DS chains of versican with L- and P-selectin and chemokines are sulfation-dependent but the interaction with CD44 is sulfation-independent. |
33(0,1,1,3) | Details |
| 12423248 | Deguchi Y, Okutsu H, Okura T, Yamada S, Kimura R, Yuge T, Furukawa A, Morimoto K, Tachikawa M, Ohtsuki S, Hosoya K, Terasaki T: Internalization of basic fibroblast growth factor at the mouse blood-brain barrier involves perlecan, a heparan sulfate proteoglycan. J Neurochem. 2002 Oct;83(2):381-9. Moreover, the -resistant binding of [125I] bFGF in TM-BBB4 cells was significantly reduced by 50% following treatment with sodium chlorate, suggesting the loss of perlecan (a core protein of heparan sulfate proteoglycan, HSPG) from the extracellular matrix of the cells. |
32(0,1,1,2) | Details |
| 19643179 | Troeberg L, Fushimi K, Scilabra SD, Nakamura H, Dive V, Thogersen IB, Enghild JJ, Nagase H: The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3. Matrix Biol. 2009 Oct;28(8):463-9. Epub 2009 Jul 28. For this purpose, we first established a novel method of purifying recombinant FLAG-tagged TIMP-3 and its inhibitory N-terminal domain (N-TIMP-3) by treating transfected HEK293 cells with sodium chlorate to prevent heparan sulfate proteoglycan-mediated TIMP-3 internalization. |
31(0,1,1,1) | Details |
| 9490645 | Esford LE, Maiti A, Bader SA, Tufaro F, Johnson P: Analysis of CD44 interactions with in murine L cell fibroblasts deficient in glycosaminoglycan synthesis: a role for J Cell Sci. 1998 Apr;111 ( Pt 7):1021-9. Treatment of L cells with sodium chlorate, an inhibitor of sulfation, also abolished inducible binding. |
7(0,0,0,7) | Details |
| 11262187 | Borgenstrom M, Tienhaara A, Spillmann D, Salmivirta M, Jalkanen M: -induced growth of S115 mouse mammary tumor cells is dependent on Exp Cell Res. 2001 Apr 1;264(2):307-14. We have previously shown that overexpression of syndecan-1 heparan sulfate proteoglycan renders S115 cells insensitive to and now demonstrate that this effect can be overcome by sodium chlorate treatment in combination with exogenous |
6(0,0,1,1) | Details |
| 9542658 | Nylander N, Smith LT, Underwood RA, Piepkorn M: Topography of amphiregulin expression in cultured human keratinocytes: colocalization with the epidermal growth factor receptor and CD44. In Vitro Cell Dev Biol Anim. 1998 Feb;34(2):182-8. Metabolic blockade of proteoglycan sulfation with sodium chlorate inhibited growth of the cells and concurrently enhanced the nuclear, but decreased the outer leading edge, labeling for amphiregulin. |
6(0,0,0,6) | Details |
| 9794764 | Maiti A, Maki G, Johnson P: TNF-alpha induction of CD44-mediated leukocyte adhesion by sulfation. . Science. 1998 Oct 30;282(5390):941-3. |
4(0,0,0,4) | Details |
| 17081280 | Djanani A, Mosheimer B, Kaneider NC, Ross CR, Ricevuti G, Patsch JR, Wiedermann CJ: Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin. J Inflamm. 2006 Nov 2;3:14. Modification of heparan sulfate proteoglycans with sodium chlorate inhibited migration whereas chemotaxis toward the chemoattractant formyl-Met-- was not affected. |
3(0,0,0,3) | Details |
| 11549250 | Kaneider NC, Egger P, Dunzendorfer S, Wiedermann CJ: Syndecan-4 as antithrombin receptor of human neutrophils. . Biochem Biophys Res Commun. 2001 Sep 14;287(1):42-6. Antithrombin inhibits chemokine-induced migration of neutrophils by activating heparan sulfate proteoglycan-dependent signaling. In vitro effects of antithrombin on human neutrophil migration in modified Boyden chambers were abolished by pretreating cells with heparinase-1, chondroitinase, sodium chlorate, and anti-syndecan-4 antibodies. |
1(0,0,0,1) | Details |
| 18037261 | Oliveira FO Jr, Alves CR, Calvet CM, Toma L, Boucas RI, Nader HB, Castro Cortes LM, Krieger MA, Meirelles Mde N, Souza Pereira MC: Trypanosoma cruzi heparin-binding proteins and the nature of the host cell -binding domain. Microb Pathog. 2008 Apr;44(4):329-38. Epub 2007 Oct 22. We have previously demonstrated the role of heparan sulfate proteoglycan in the attachment and invasion of T. cruzi in cardiomyocytes. |
1(0,0,0,1) | Details |
| 9221767 | Tolar M, Marques MA, Harmony JA, Crutcher KA: Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated. J Neurosci. 1997 Aug 1;17(15):5678-86. Effective inhibitors of neurotoxicity of both the apoE peptides and the apoE fragment include heparan sodium chlorate and heparinase, the low-density lipoprotein (LDL) receptor-related protein receptor-associated protein, and a polyclonal anti-LDL receptor-related protein antibody. These results suggest that the neurotoxicity of the 22 kDa thrombin cleavage fragment of apoE and related peptides is receptor-mediated, and that the most likely candidate receptor is a heparan sulfate proteoglycan-LDL receptor-related protein complex. |
1(0,0,0,1) | Details |
| 15292202 | Gingis-Velitski S, Zetser A, Kaplan V, Ben-Zaken O, Cohen E, Levy-Adam F, Bashenko Y, Flugelman MY, Vlodavsky I, Ilan N: Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. J Biol Chem. 2004 Oct 15;279(42):44084-92. Epub 2004 Jul 29. Addition of or xylosides to cell cultures resulted in a pronounced accumulation of, heparanase in the culture medium, whereas sodium chlorate had no such effect. Moreover, cellular uptake of heparanase was markedly reduced in HS-deficient CHO-745 mutant cells, heparan sulfate proteoglycan-deficient HT-29 colon cancer cells, and heparinase-treated cells. |
1(0,0,0,1) | Details |
| 8096145 | Patel M, Yanagishita M, Roderiquez G, Bou-Habib DC, Oravecz T, Hascall VC, Norcross MA: Cell-surface heparan sulfate proteoglycan mediates HIV-1 infection of T-cell lines. AIDS Res Hum Retroviruses. 1993 Feb;9(2):167-74. Sulfation of glycosaminoglycans HS chains was critical to viral entry as shown by inhibition of viral infection with sodium chlorate and its specific reversal with exogenous addition. |
1(0,0,0,1) | Details |
| 8150210 | Bansal R, Pfeiffer SE: Inhibition of protein and lipid sulfation in oligodendrocytes blocks biological responses to FGF-2 and retards cytoarchitectural maturation, but not developmental lineage progression. Dev Biol. 1994 Apr;162(2):511-24. Sulfation was inhibited in this system by growing cells in sodium chlorate, a competitive inhibitor of sulfation. First, heparan sulfate proteoglycan is a necessary cofactor for the environmental regulation by FGF-2 of nontransformed oligodendrocyte progenitors, including both the mitogenic response and the inhibition of terminal differentiation at a specific stage of the lineage. |
1(0,0,0,1) | Details |
| 8780517 | Krufka A, Guimond S, Rapraeger AC: Two hierarchies of FGF-2 signaling in mitogenic stimulation and high-affinity binding/receptor transphosphorylation. Biochemistry. 1996 Aug 27;35(34):11131-41. FGF-2 activates multiple signaling pathways by a cell surface signaling complex assembled with FGF, its receptor tyrosine kinase, and heparan sulfate proteoglycan. |
1(0,0,0,1) | Details |
| 14684735 | Gao R, Brigstock DR: Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha (v) beta (3) and heparan sulfate proteoglycan. J Biol Chem. 2004 Mar 5;279(10):8848-55. Epub 2003 Dec 17. Third, destruction or inhibition of synthesis of cell surface HSPGs with, respectively, heparinase or sodium chlorate abrogated HSC adhesion to CCN2 (4). |
1(0,0,0,1) | Details |
| 11801740 | Kaneider NC, Reinisch CM, Dunzendorfer S, Romisch J, Wiedermann CJ: Syndecan-4 mediates antithrombin-induced chemotaxis of human peripheral blood lymphocytes and monocytes. J Cell Sci. 2002 Jan 1;115(Pt 1):227-36. Effects of antithrombin were abolished by pretreating cells with heparinase-1, chondroitinase, sodium chlorate and anti-syndecan-4 antibodies. Antithrombin inhibits chemokine-induced migration of neutrophils by activating heparan sulfate proteoglycan-dependent signaling. |
1(0,0,0,1) | Details |
| 12810721 | Fuki IV, Blanchard N, Jin W, Marchadier DH, Millar JS, Glick JM, Rader DJ: Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway. J Biol Chem. 2003 Sep 5;278(36):34331-8. Epub 2003 Jun 16. Inhibition of proteoglycan sulfation by sodium chlorate or incubation of cells with labeled lipoproteins in the presence of (100 microg/ml) abolished bridging effects of EL. |
1(0,0,0,1) | Details |
| 1484387 | Kallapur SG, Akeson RA: The neural cell adhesion molecule (NCAM) binding domain binds to cell surface heparan sulfate proteoglycans. J Neurosci Res. 1992 Dec;33(4):538-48. Furthermore, inhibition of HSPG sulfation with sodium chlorate also decreased the adhesion of B35 cells to the HBD peptide. |
0(0,0,0,0) | Details |