| Name | acetylcholine receptor (protein family or complex) |
|---|---|
| Synonyms | Acetylcholine receptor; Acetylcholine receptors |
| Name | spinosad |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20062520 | Baxter SW, Chen M, Dawson A, Zhao JZ, Vogel H, Shelton AM, Heckel DG, Jiggins CD: Mis-spliced transcripts of nicotinic acetylcholine receptor alpha6 are associated with field evolved spinosad resistance in Plutella xylostella (L.). PLoS Genet. 2010 Jan;6(1):e1000802. Epub 2010 Jan 8. Spinosad is a new, low-environmental-risk insecticide that primarily targets nicotinic acetylcholine receptors (nAChR) and is effective against a wide range of pest species. |
87(1,1,2,2) | Details |
| 15366583 | Mayes MA, Thompson GD, Husband B, Miles MM: Spinosad toxicity to pollinators and associated risk. Rev Environ Contam Toxicol. 2003;179:37-71. Spinosad causes neurological effects in insects that are consistent with the general activation of nicotinic acetylcholine receptors but by a mechanism that is novel among known insecticide compounds. |
81(1,1,1,1) | Details |
| 17439546 | Gao JR, Deacutis JM, Scott JG: The nicotinic acetylcholine receptor subunit Mdalpha6 from Musca domestica is diversified via post-transcriptional modification. Insect Mol Biol. 2007 Jun;16(3):325-34. Epub 2007 Apr 17. Recent studies showed that deletion of a nicotinic acetylcholine receptor (nAChR) subunit gene, Dalpha6 in Drosophila melanogaster results in a strain that is resistant to spinosad, indicating that Dalpha6 is important for the toxic action of this insecticide. |
7(0,0,1,2) | Details |
| 18092998 | Gao JR, Deacutis JM, Scott JG: The nicotinic acetylcholine receptor subunits Mdalpha5 and Mdbeta3 on autosome 1 of Musca domestica are not involved in spinosad resistance. Insect Mol Biol. 2007 Dec;16(6):691-701. Spinosad is a relatively new insecticide that exerts its toxic action via nicotinic acetylcholine receptors (nAChRs). |
6(0,0,1,1) | Details |
| 17244547 | Perry T, McKenzie JA, Batterham P: A Dalpha6 knockout strain of Drosophila melanogaster confers a high level of resistance to spinosad. Insect Biochem Mol Biol. 2007 Feb;37(2):184-8. Epub 2006 Dec 5. A null mutation of the nicotinic acetylcholine receptor (nAChR) subunit Dalpha6, in Drosophila melanogaster, confers 1181-fold resistance to a new and increasingly important biopesticide, spinosad. |
6(0,0,1,1) | Details |
| 12425057 | Ishaaya I, Kontsedalov S, Mazirov D, Horowitz AR: Biorational agents--mechanism and importance in IPM and IRM programs for controlling agricultural pests. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2001;66(2a):363-74. In addition, efforts have been made to develop compounds acting selectively on groups of insects by inhibiting or enhancing biochemical sites such as respiration (diafenthiuron), the nicotinyl acetylcholine receptors (imidacloprid and acetamiprid), the GABA receptors (avermectins), the salivary glands of sucking pests (pymetrozine) and others. Among the most recent novel insecticides with selective properties are novaluron, thiamethoxam, emamectin and spinosad. |
1(0,0,0,1) | Details |
| 20150928 | Kirst HA: The spinosyn family of insecticides: realizing the potential of natural products research. J Antibiot. 2010 Mar;63(3):101-11. Epub 2010 Feb 12. Spinosad is a defined combination of the two principal fermentation factors, spinosyns A and D. The spinosyns have a unique mechanism of action (MOA) involving disruption of nicotinic acetylcholine receptors. |
1(0,0,0,1) | Details |
| 19944756 | Orr N, Chouinard SW, Cook KR, Geng C, Gifford JM, Gustafson GD, Hasler JM, Larrinua IM, Letherer TJ, Mitchell JC, Pak WL, Salgado VL, Sparks TC, Stilwell GE, Watson GB: A spinosyn-sensitive Drosophila melanogaster nicotinic acetylcholine receptor identified through chemically induced target site resistance, resistance gene identification, and heterologous expression. Insect Biochem Mol Biol. 2009 Nov 26. Strains of Drosophila melanogaster with resistance to the insecticides spinosyn A, spinosad, and spinetoram were produced by chemical mutagenesis. The two strains that were initially characterized were subsequently found to have mutations in the gene encoding the nicotinic acetylcholine receptor (nAChR) subunit Dalpha6. |
1(0,0,0,1) | Details |