Protein Information

Name 4 hydroxyphenylpyruvate dioxygenase
Synonyms 4 hydroxyphenylpyruvate dioxygenase; PPD; 4 hydroxyphenylpyruvic acid dioxygenase; 4 hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; 4 hydroxyphenylpyruvic acid dioxygenases…

Compound Information

Name sulcotrione
CAS 2-[2-chloro-4-(methylsulfonyl)benzoyl]-1,3-cyclohexanedione

Reference List

PubMed Abstract RScore(About this table)
18389008 Turick CE, Caccavo F Jr, Tisa LS: Pyomelanin is produced by Shewanella algae BrY and affected by exogenous iron. Can J Microbiol. 2008 Apr;54(4):334-9.

In the absence of ascorbate, melanin production was inhibited by the 4-hydroxyphenylpyruvate dioxygenase inhibitor sulcotrione and by concentrations of Fe > or= 0.38 mmol L (-1).
31(0,1,1,1) Details
12232420 Secor J: Inhibition of Barnyardgrass 4-Hydroxyphenylpyruvate Dioxygenase by Sulcotrione. Plant Physiol. 1994 Dec;106(4):1429-1433.
163(2,2,2,3) Details
18381065 Lee CM, Yeo YS, Lee JH, Kim SJ, Kim JB, Han NS, Koo BS, Yoon SH: Identification of a novel 4-hydroxyphenylpyruvate dioxygenase from the soil metagenome. Biochem Biophys Res Commun. 2008 May 30;370(2):322-6. Epub 2008 Mar 31.

The HPPD-specific beta-triketone herbicide, sulcotrione, inhibited YS103B pigmentation.
2(0,0,0,2) Details
9570125 Keon J, Hargreaves J: Isolation and heterologous expression of a gene encoding 4-hydroxyphenylpyruvate dioxygenase from the wheat leaf-spot pathogen, Mycosphaerella graminicola. FEMS Microbiol Lett. 1998 Apr 15;161(2):337-43.

Pigment development in these cultures was prevented by the HPPD inhibitor sulcotrione.
2(0,0,0,2) Details
7597701 Ellis MK, Whitfield AC, Gowans LA, Auton TR, Provan WM, Lock EA, Smith LL: Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dione. Toxicol Appl Pharmacol. 1995 Jul;133(1):12-9.

2(0,0,0,2) Details
12681479 Falk J, Andersen G, Kernebeck B, Krupinska K: Constitutive overexpression of barley 4-hydroxyphenylpyruvate dioxygenase in tobacco results in elevation of the vitamin E content in seeds but not in leaves. FEBS Lett. 2003 Apr 10;540(1-3):35-40.

With the aim to enhance the plant vitamin E content, the barley gene encoding 4-hydroxyphenylpyruvate dioxygenase was overexpressed in tobacco plants under control of the 35S promoter.
Transgenic lines have a higher capacity for homogentisate biosynthesis as evident by a more than 10-fold higher resistance towards the bleaching herbicide sulcotrione.
1(0,0,0,1) Details
16008097 Falk J, Brosch M, Schafer A, Braun S, Krupinska K: Characterization of transplastomic tobacco plants with a plastid localized barley 4-hydroxyphenylpyruvate dioxygenase. J Plant Physiol. 2005 Jul;162(7):738-42.

The expression of the hpd gene expression cassette was demonstrated by accumulation of the hpd gene-specific transcript and by a higher resistance of the transgenic seedlings towards the HPD specific inhibitor sulcotrione.
1(0,0,0,1) Details