| Name | cholinesterase |
|---|---|
| Synonyms | Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase… |
| Name | TEPP |
|---|---|
| CAS | tetraethyl diphosphate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18961236 | Beezer AE, Stubbs CD: Application of flow microcalorimetry to analytical problems-I Determination of organophosphorus pesticides by inhibition of cholinesterase. Talanta. 1973 Jan;20(1):27-31. One direct inhibitor (TEPP) and one latent inhibitor (parathion) were investigated. |
2(0,0,0,2) | Details |
| 13489171 | HOBBIGER F: Protection against the lethal effects of organophosphates by -2- methiodide. Br J Pharmacol Chemother. 1957 Dec;12(4):438-46. Two types of organophosphates were used: ethyl (TEPP), E 600, Ro 3-0340, and Ro 3-0422 which form with true cholinesterase a diethylphosphoryl enzyme (1) and DFP, D 600, and Ro 3-0351 which form with true cholinesterase a diisopropylphosphoryl enzyme (2).In vitro and under the experimental conditions used more than 50% reactivation of (1) was obtained within 1 hr. by concentrations of P-2-AM ranging from 0.5 to 1x10 (-5) M; 30 times higher concentrations of the oxime were required to achieve the same effect with (2). In vivo reactivation of phosphorylated true cholinesterases in blood amounted to 10 to 24% within the first 30 min. if 25 mg./kg. |
2(0,0,0,2) | Details |
| 13059622 | LEACH PH: Organic poisoning in general practice; parathion, TEPP, HEPT, EPN and others. Calif Med. 1953 Jun;78(6):491-5. The organic radical has the specific effect of inactivating cholinesterase in the body. |
2(0,0,0,2) | Details |
| 6724212 | Wolthuis OL, Vanwersch RA: Behavioral changes in the rat after low doses of cholinesterase inhibitors. Fundam Appl Toxicol. 1984 Apr;4(2 Pt 2):S195-208. TEPP and sarin at doses up to 30% LD50 were without effects. |
2(0,0,0,2) | Details |
| 13304690 | HALEY TJ: The insecticides; their hazard in industry and in the home. Calif Med. 1956 Apr;84(4):258-64. Organic phosphates destroy cholinesterase and produce effects related to overstimulation of the cholinergic branch of the autonomic nervous system. These compounds may be grouped in the following order of decreasing toxicity: TEPP, HETP, parathion, OMPA, ENP, aldrin, chlorophenothane, toxaphene, gamma benzene hexachloride, malathon and chlordane. |
1(0,0,0,1) | Details |
| 16481169 | Srinivas Rao C, Venkateswarlu V, Achaiah G: Quaternary salts of 4,3' and 4,4' bis-pyridinium monooximes. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2134-8. Epub 2006 Feb 14. Their ability to reactivate tetraethylpyrophosphate (TEPP) inhibited mouse total brain cholinesterase was investigated and compared with the conventional oxime 2-pyridinealdoxime chloride (2-PAM). |
81(1,1,1,1) | Details |
| 11926204 | Perry NS, Houghton PJ, Jenner P, Keith A, Perry EK: Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo. Phytomedicine. 2002 Jan;9(1):48-51. Choline esterase activity was measured post mortem in three areas of the brain, both in the absence and presence of TEPP, a specific butylcholine esterase inhibitor, and was found to be significantly reduced in the striatum with both doses and also in the hippocampus at the higher dose. |
33(0,1,1,3) | Details |
| 18468398 | Petroianu GA: The history of cholinesterase inhibitors: who was Moschnin (e)? . Pharmazie. 2008 Apr;63(4):325-7. The synthesis of the first organophosphate cholinesterase inhibitor (tetraethyl TEPP) is often credited to the French organic chemist Philippe de Clermont, working in the laboratories of Adolphe Wurtz in Paris. |
32(0,1,1,2) | Details |
| 13489182 | DE BURGH DALY M: The effects of anticholinesterases on the bronchioles and pulmonary blood vessels in isolated perfused lungs of the dog. Br J Pharmacol Chemother. 1957 Dec;12(4):504-12. The effects of two potent inhibitors of cholinesterase, isopropylmethylphosphonofluoridate (sarin) and ethyl (TEPP), were investigated on the bronchioles and pulmonary blood vessels in isolated dog lung preparations perfused with heparinized blood and ventilated artificially. |
31(0,1,1,1) | Details |
| 19435147 | Petroianu GA: The synthesis of phosphor ethers: who was Franz Anton Voegeli? . Pharmazie. 2009 Apr;64(4):269-75. The synthesis of the first organophosphate cholinesterase inhibitor (tetraethyl TEPP) is credited to the French organic chemist Philippe de Clermont (1831-1921) and to the Russian chemist Wladimir P. |
31(0,1,1,1) | Details |
| 13268462 | RANDALL LO, CONROY CE, FERRUGGIA TM, KAPPELL BH, KNOEPPEL CR: Pharmacology of the anticholinesterase drugs; mestinon, prostigmin, tensilon and TEPP. Am J Med. 1955 Nov;19(5):673-8. |
6(0,0,1,1) | Details |
| 7114900 | Soliman SA, Sovocool GW, Curley A, Ahmed NS, El-Fiki S, El-Sebae AK: Two acute human poisoning cases resulting from exposure to diazinon transformation products in Egypt. Arch Environ Health. 1982 Jul-Aug;37(4):207-12. Sulfotepp and monothiono-TEPP were two of the identified products in the sample, both of which are much more toxic than diazinon. Plasma and red blood cell cholinesterase activity values were determined in blood samples obtained from both individuals at various times after the incident. |
3(0,0,0,3) | Details |