Protein Information

Name IkappaB kinase
Synonyms CHUK; IkappaB kinase; Conserved helix loop ubiquitous kinase; Conserved helix loop helix ubiquitous kinase; Conserved helix loop helix ubiquitous kinase variant; I kappa B kinase 1; I kappa B kinase alpha; IKBKA…

Compound Information

Name eugenol
CAS 2-methoxy-4-(2-propen-1-yl)phenol

Reference List

PubMed Abstract RScore(About this table)
19851710 Manikandan P, Vinothini G, Vidya Priyadarsini R, Prathiba D, Nagini S: Eugenol inhibits cell proliferation via NF-kappaB suppression in a rat model of gastric carcinogenesis induced by MNNG. Invest New Drugs. 2009 Oct 23.

In the present study, we investigated the modulatory effects of eugenol on NF-kappaB signaling in a rat model of gastric carcinogenesis induced by N-methyl-N (')-nitro-N-nitrosoguanidine (MNNG) by analysing the expression of nuclear factor-kappaB (NF-kappaB) family members ((NF-kappaB (p50 and p65), inhibitor of kappaB alpha (IkappaBalpha), phosphorylated IkappaBalpha (p-IkappaBalpha), IkappaB kinase beta (IKKbeta)) and the NF-kappaB target genes that promote (e.g., cyclin D1, cyclin B and PCNA) or inhibit (e.g., p53, p21, and Gadd45) cell proliferation and cell survival.		 31(0,1,1,1) Details