Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name methiocarb
CAS

Reference List

PubMed Abstract RScore(About this table)
10826201 Jensen SE: Mechanisms associated with methiocarb resistance in Frankliniella occidentalis (Thysanoptera: Thripidae). J Econ Entomol. 2000 Apr;93(2):464-71.

Assays of acetylcholinesterase sensitivity to inhibition by methiocarb, dichlorvos, and eserine suggested insensitive acetylcholinesterase in two of the resistant populations.
87(1,1,2,2) Details
18470629 Essawy AE, Abdelmeguied NE, Radwan MA, Hamed SS, Hegazy AE: Neuropathological effect of carbamate molluscicides on the land snail, Eobania vermiculata. Cell Biol Toxicol. 2009 Jun;25(3):275-90. Epub 2008 May 10.

However, methomyl exhibited more potency in reducing AChE activity than methiocarb.
83(1,1,1,3) Details
8568832 Buronfosse T, Moroni P, Benoit E, Riviere JL: Stereoselective sulfoxidation of the pesticide methiocarb by flavin-containing monooxygenase and cytochrome P450-dependent monooxygenases of rat liver microsomes. J Biochem Toxicol. 1995 Aug;10(4):179-89.

The acetylcholinesterase inhibition properties of methiocarb and its main metabolites were also investigated.
81(1,1,1,1) Details
19148665 Thierauf A, Gnann H, Bohnert M, Vennemann B, Auwarter V, Weinmann W: Suicidal poisoning with mercaptodimethur-morphological findings and toxicological analysis. Int J Legal Med. 2009 Jul;123(4):327-31. Epub 2009 Jan 16.

An 80-year-old woman died of an intoxication with methiocarb (mercaptodimethur), a carbamate type pesticide and as such a reversible inhibitor of the acetylcholinesterase.
81(1,1,1,1) Details
19934164 Moser VC, McDaniel KL, Phillips PM, Lowit AB: Time-course, dose-response, and age comparative sensitivity of N-methyl carbamates in rats. Toxicol Sci. 2010 Mar;114(1):113-23. Epub 2009 Nov 24.

N-Methyl carbamate insecticides are reversible inhibitors of central and peripheral acetylcholinesterase (ChE).
To study potential age-related differences, we evaluated seven carbamates (carbaryl, carbofuran, formetanate, methiocarb, methomyl, oxamyl, and propoxur) in preweanling (17 days old or postnatal day [PND] 17) male rats.
1(0,0,0,1) Details
19410293 Calisi A, Lionetto MG, Schettino T: Pollutant-induced alterations of granulocyte morphology in the earthworm Eisenia foetida. Ecotoxicol Environ Saf. 2009 Jul;72(5):1369-77. Epub 2009 May 2.

Results showed consistent enlargement of earthworm granulocytes induced by exposure to either copper sulfate or methiocarb.
In order to verify the applicability of morphometric granulocyte alteration, a battery of standardized biomarkers such as lysosomal membrane stability, metallothionein induction, or acetylcholinesterase (AChE) inhibition were also determined.
1(0,0,0,1) Details