| Name | sodium channel (protein family or complex) |
|---|---|
| Synonyms | Sodium channel |
| Name | cismethrin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2452970 | Bloomquist JR, Soderlund DM: Pyrethroid insecticides and DDT modify alkaloid-dependent sodium channel activation and its enhancement by sea anemone toxin. Mol Pharmacol. 1988 May;33(5):543-50. The effects of saturating concentrations of DDT [1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane] and the pyrethroid insecticides cismethrin and deltamethrin on alkaloid-dependent activation of the voltage-sensitive sodium channel were studied using measurements of 22Na+ uptake into mouse brain synaptosomes. |
83(1,1,1,3) | Details |
| 11102831 | Lee SH, Soderlund DM: The V410M mutation associated with pyrethroid resistance in Heliothis virescens reduces the pyrethroid sensitivity of house fly channels expressed in Xenopus oocytes. Insect Biochem Mol Biol. 2001 Jan;31(1):19-29. The effects of the V410M mutation on the voltage dependence and cismethrin sensitivity of Vssc1 channels were indistinguishable from those caused by another sodium channel point mutation, replacement of Leu1014 by (L1014F), that is the cause of knockdown resistance to pyrethroids in the house fly. |
9(0,0,1,4) | Details |
| 11829409 | Soderlun DM, Lee SH: Point mutations in homology domain II modify the sensitivity of rat Nav1.8 channels to the pyrethroid insecticide cismethrin. Neurotoxicology. 2001 Dec;22(6):755-65. To assess the impact of these residues as determinants of pyrethroid sensitivity in another sequence context, we mutated the corresponding positions of the rat pyrethroid-sensitive, TTX-resistant peripheral nerve sodium channel (rNav1.8; also called SNS or PN3) and determined the sensitivity of native and mutated channels expressed in Xenopus oocytes to the pyrethroid insecticide cismethrin. |
8(0,0,1,3) | Details |
| 10196741 | Lee SH, Smith TJ, Knipple DC, Soderlund DM: Mutations in the house fly Vssc1 sodium channel gene associated with super-kdr resistance abolish the pyrethroid sensitivity of Vssc1/tipE channels expressed in Xenopus oocytes. Insect Biochem Mol Biol. 1999 Feb;29(2):185-94. However, M918T/L1014F channels were completely insensitive to high concentrations of the pyrethroids cismethrin and cypermethrin. |
2(0,0,0,2) | Details |
| 15337272 | Choi JS, Soderlund DM: Cyclosporin A and deltamethrin block the downregulation of Nav1.8 channels expressed in Xenopus oocytes. Neurosci Lett. 2004 Sep 9;367(3):389-93. The Nav1.8 sodium channel isoform, expressed in sensory neurons and implicated in pain responses, is known to be upregulated in Xenopus oocytes by agents that activate protein kinase A. |
2(0,0,0,2) | Details |
| 10662599 | Forshaw PJ, Lister T, Ray DE: The role of voltage-gated channels in type II pyrethroid insecticide poisoning. Toxicol Appl Pharmacol. 2000 Feb 15;163(1):1-8. This effect would be expected to amplify the sodium channel-mediated signs of poisoning produced by pyrethroids. This was followed by deltamethrin (1.5 or 2 mg/kg iv) or the type I pyrethroid cismethrin (4 mg/kg iv). |
1(0,0,0,1) | Details |
| 16051293 | Choi JS, Soderlund DM: Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Na v 1.8 channels expressed in Xenopus oocytes. Toxicol Appl Pharmacol. 2006 Mar 15;211(3):233-44. Epub 2005 Jul 26. This paper describes the action of 11 structurally diverse commercial pyrethroid insecticides on the rat Na v 1.8 sodium channel isoform, the principal carrier of the tetrodotoxin-resistant, pyrethroid-sensitive current of sensory neurons, expressed in Xenopus laevis oocytes. All 11 compounds produced characteristic tail currents following a depolarizing pulse that ranged from rapidly-decaying monoexponential currents (allethrin, cismethrin and permethrin) to persistent biexponential currents (cyfluthrin, cyhalothrin, cypermethrin and deltamethrin). |
1(0,0,0,1) | Details |
| 19766671 | Breckenridge CB, Holden L, Sturgess N, Weiner M, Sheets L, Sargent D, Soderlund DM, Choi JS, Symington S, Clark JM, Burr S, Ray D: Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides. Neurotoxicology. 2009 Nov;30 Suppl 1:S17-31. Epub 2009 Sep 18. Neurotoxicity and mechanistic data were collected for six alpha-cyano pyrethroids (beta-cyfluthrin, cypermethrin, deltamethrin, esfenvalerate, fenpropathrin and lambda-cyhalothrin) and up to six non-cyano containing pyrethroids (bifenthrin, S-bioallethrin [or allethrin], permethrin, pyrethrins, resmethrin [or its cis-isomer, cismethrin] and tefluthrin under standard conditions. Factor analysis and multivariate dissimilarity analysis were employed to evaluate four independent data sets comprised of (1) fifty-six behavioral and physiological parameters from an acute neurotoxicity functional observatory battery (FOB), (2) eight electrophysiological parameters from voltage clamp experiments conducted on the Na (v) 1.8 sodium channel expressed in Xenopus oocytes, (3) indices of efficacy, potency and binding calculated for influx across neuronal membranes, membrane depolarization and released from rat brain synaptosomes and (4) changes in chloride channel open state probability using a patch voltage clamp technique for membranes isolated from mouse neuroblastoma cells. |
1(0,0,0,1) | Details |
| 9474777 | Smith TJ, Lee SH, Ingles PJ, Knipple DC, Soderlund DM: The L1014F point mutation in the house fly Vssc1 sodium channel confers knockdown resistance to pyrethroids. Insect Biochem Mol Biol. 1997 Oct;27(10):807-12. The pyrethroid insecticide cismethrin prolonged the current carried by Vssc1/tipE channels during a depolarizing pulse and induced a tail current after repolarization. |
1(0,0,0,1) | Details |
| 2702491 | Gilbert ME, Mack CM, Crofton KM: Pyrethroids and enhanced inhibition in the hippocampus of the rat. Brain Res. 1989 Jan 16;477(1-2):314-21. The GABAergic properties of the pyrethroids were assessed by examining paired pulse inhibition before and after oral treatment with 20 mg/kg of cismethrin (Type I), 20 mg/kg of fenvalerate, or 10 mg/kg of deltamethrin (Type IIs). |
0(0,0,0,0) | Details |