Protein Information

Name proliferating cell nuclear antigen
Synonyms Cyclin; DNA polymerase delta auxillary protein; PCNA; Proliferating cell nuclear antigen; DNA polymerase delta auxillary proteins; Proliferating cell nuclear antigens

Compound Information

Name dibutyl phthalate
CAS dibutyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
11934529 Mylchreest E, Sar M, Wallace DG, Foster PM: Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di (n-butyl) phthalate. Reprod Toxicol. 2002 Jan-Feb;16(1):19-28.


Focal areas of hyperplasia had increased numbers of Leydig cells positive for proliferating cell nuclear antigen (PCNA).
2(0,0,0,2) Details
15461258 Yu Z, Zhang L, Wu D: [Effects of three environmental estrogens on expression of proliferation and apoptosis-associated genes in PEO4 cells]. Wei Sheng Yan Jiu. 2004 Jul;33(4):404-6.

OBJECTIVE: This study was designed to investigate the molecular mechanisms of proliferation and apoptosis by environmental estrogens (n-4-nonylphenol, NP; Bisphenol A, BisA; Dibutyl Phthalate, DBP) in ovarian cancer PEO4 cells.
After various concentration of NP, BisA and DBP treatment for 72h, the cells were harvested and detected mRNA and protein expression of PCNA, bcl-2 and bax by reverse transcription-polymerase chain reaction and immunohistochemistry, respectively.
2(0,0,0,2) Details
17493787 Bredhult C, Backlin BM, Olovsson M: Effects of some endocrine disruptors on the proliferation and viability of human endometrial endothelial cells in vitro. Reprod Toxicol. 2007 Jun;23(4):550-9. Epub 2007 Mar 31.


Cell proliferation was studied using immunocytochemistry for PCNA expression and a 5-bromo-2'-deoxyuridine assay.
1(0,0,0,1) Details