Protein Information

Name CD11c
Synonyms CD11C; CD11c; CD11c antigen; ITGAX; Integrin alpha X; Integrin alpha X precursor; Leu M5; CD11cs…

Compound Information

Name dibutyl phthalate
CAS dibutyl 1,2-benzenedicarboxylate

Reference List

PubMed Abstract RScore(About this table)
17083357 Imai Y, Kondo A, Iizuka H, Maruyama T, Kurohane K: Effects of phthalate esters on the sensitization phase of contact hypersensitivity induced by fluorescein isothiocyanate. Clin Exp Allergy. 2006 Nov;36(11):1462-8.


FITC-positive cells were characterized with anti-CD11c and anti-CD11b by three-colour flow cytometry.
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17259732 Maruyama T, Iizuka H, Tobisawa Y, Shiba T, Matsuda T, Kurohane K, Imai Y: Influence of local treatments with capsaicin or allyl isothiocyanate in the sensitization phase of a fluorescein-isothiocyanate-induced contact sensitivity model. Int Arch Allergy Immunol. 2007;143(2):144-54. Epub 2007 Jan 26.

BACKGROUND: In fluorescein isothiocyanate (FITC)-induced contact hypersensitivity models, dibutyl phthalate has been empirically used as a solvent ingredient.
The appearance of FITC-presenting CD11c-positive cells in the draining lymph nodes was detected by flow cytometry.
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20173025 Larson RP, Zimmerli SC, Comeau MR, Itano A, Omori M, Iseki M, Hauser C, Ziegler SF: Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses. J Immunol. 2010 Mar 15;184(6):2974-84. Epub 2010 Feb 19.

The reduced response by TSLPR-deficient mice is likely due to decreased frequency and reduced T cell stimulatory function of skin-derived Ag-bearing FITC (+) CD11c (+) dendritic cells in draining lymph nodes following FITC sensitization.
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