Protein Information

Name chloride channel (protein family or complex)
Synonyms chloride channel

Compound Information

Name abamectin
CAS

Reference List

PubMed Abstract RScore(About this table)
7935817 Cully DF, Vassilatis DK, Liu KK, Paress PS, Van der Ploeg LH, Schaeffer JM, Arena JP: Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature. 1994 Oct 20;371(6499):707-11.

Abamectin (avermectin B1a) is a miticide and insecticide used in crop protection.
3(0,0,0,3) Details
1375788 Bloomquist JR: Intrinsic lethality of chloride-channel-directed insecticides and convulsants in mammals. Toxicol Lett. 1992 May;60(3):289-98.

In contrast, the toxicities of lindane, abamectin, and the bicyclic convulsants TBPS and a TBOB analog were approximately the same by either route of administration.
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8054658 Bloomquist JR: Cyclodiene resistance at the insect GABA receptor/chloride channel complex confers broad cross resistance to convulsants and experimental phenylpyrazole insecticides. Arch Insect Biochem Physiol. 1994;26(1):69-79.

In contrast, this strain was susceptible to cypermethrin and the avermectins MK-243, abamectin, and abamectin 8,9-oxide.
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19133471 Zhou XM, Wu QJ, Zhang YJ, Bai LY, Huang XY: Cloning and characterization of a GABA receptor from Plutella xylostella (Lepidoptera: Plutellidae). J Econ Entomol. 2008 Dec;101(6):1888-96.

A full-length cDNA, with an open reading frame (ORF) of 1,449 bp, encoding a subunit of the gamma-aminobutyric acid (GABA)-activated chloride channel was isolated from Plutella xylostella (L.) (Lepidoptera: Plutellidae) (GenBank accession no.
When expressed in Xenopus laevis oocytes, the subunit assembled as a functional homomeric complex activated by GABA and abamectin in a dose-dependent manner.
1(0,0,0,1) Details