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Vollrath V, Wielandt AM, Iruretagoyena M, Chianale J: Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene. Biochem J. 2006 May 1;395(3):599-609.
A similar pattern of co-induction of Mrp2 and GCLC genes was also observed in mouse (Hepa 1-6) and human (HepG2) hepatoma cells treated with BHA, beta-NF (beta-naphthoflavone), 2,4,5-T (trichlorophenoxyacetic acid) or 2AAF (2-acetylaminofluorene), suggesting that these genes share common mechanism (s) of transcriptional activation in response to exposure to xenobiotics. |
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