| Name | ATPase |
|---|---|
| Synonyms | ATP7A; MK; ATPase; Cation transporting ATPase; ATP7A protein; ATPase Cu(2+) transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1… |
| Name | perfluidone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6238687 | Olorunsogo OO, Malomo SO: Mitochondrial bioenergetics during exposure of rats to perfluidone, a fluorinated arylalkylsulphonamide. Chem Biol Interact. 1984 Nov;52(1):67-78. Mitochondria isolated from the livers of rats intraperitoneally exposed to varying doses (0-80 mg/kg body wt.) of perfluidone (1,1,1-trifluoro-N-(2 methyl-4-(phenylsulphonyl) phenyl methanesulphonamide), a fluorinated arylalkylsulphonamide pesticide, exhibit the following dose-dependent features: (i) increased state-4 respiration: stimulation being maximal (greater than or equal to 400%) at 80 mg perfluidone per kg body wt.), (ii) release of respiratory control by least respiratory control ratios (RCRs) (less than or equal to 1.2) were obtained at 80 mg perfluidone per kg body wt., (iii) reduced /O ratios, (iv) increased mitochondrial passive swelling, (vi) reduced rates of mitochondrial ejection during oxidation, (vi) reduced rates of respiration-dependent Ca2+ accumulation and (vii) an enhanced oligomycin-sensitive ATPase action. |
31(0,1,1,1) | Details |
| 2992524 | Olorunsogo OO, Malomo SO, Bababunmi EA: Protonophoric properties of fluorinated arylalkylsulfonamides. Biochem Pharmacol. 1985 Aug 15;34(16):2945-52. According to Mitchell's chemiosmotic theory, lipophilic weak-acid uncoupling agents act by transporting protons across the inner mitochondrial membrane and thus destroying the -electrochemical potential gradient required for ATP synthesis and ion transport. 1:1:1-Trifluoro-N-[2-methyl-4-(phenylsulphonyl) phenyl] methanesulphonamide (Perfluidone), a pre- and post-emergence herbicide (at 20 microM concentration), in isolated rat-liver mitochondria caused (1) a 2-fold stimulation of metabolic state-4 respiration, (2) a reduction of respiratory control ratio (RCR) by at least 50%, (3) an enhancement of latent ATPase activity by 40%, (4) a significant passive swelling of mitochondria in 0.15 N NH4Cl (delta A520 = -0.46 +/- 0.003), (5) intrusion during state-4 respiration (356 ng H+/min/mg protein; ng H+/min/mg protein with 5 microM perfluidone), and (6) at least 100% stimulation of oligomycin-inhibited respiration. |
31(0,1,1,1) | Details |
| 3160138 | Olorunsogo OO, Malomo SO: Sensitivity of oligomycin-inhibited respiration of isolated rat liver mitochondria to perfluidone, a fluorinated arylalkylsulfonamide. Toxicology. 1985 Jun 14;35(3):231-40. Our results also show an enhanced oligomycin-sensitive ATPase action in intact mitochondria incubated with ATP and varying concentrations of perfluidone. |
7(0,0,1,2) | Details |